Abstract Details

Title National Trends in Heart Failure–Associated Cerebrovascular Disease Mortality Among U.S. Adults, 1999–2023: A 25-Year Analysis of Rates and Disparities

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P7 - Poster Session 7 (8:00 AM-9:00 AM)

Poster/Presentation
Number 4-020

Objective This study aims to examine the mortality trends in Heart failure and associated cerebrovascular disease among adults in the United States.

Background Cerebrovascular diseases and heart failure (HF) can coexist as contributors in adults morbidity and mortality in the United States with potential for serious complications.

Design/Methods Data from CDC WONDER (1999–2023) identified U.S mortality rates in adults aged (+25) with cerebrovascular diseases (ICD-10: I60-I69) and heart failure (ICD-10: I50 heart failure) as leading causes of death. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated. Trends were analyzed using Joinpoint regression to estimate annual percent change (APC) and Average annual percent change (AAPC).

Results Between 1999 and 2023, a total of 541,325 deaths among adults (+25) were attributed to cerebrovascular disease and heart failure. The AAMR significantly declined from 14.74 to 10.76 (AAPC: -1.34%, 95% CI: -2.11 to -0.56; p = 0.008). Gender-stratified trends showed higher mortality in women (312,995) than men (228,330) with higher AAMR in men (15.47 in 1999 to 12.16 in 2023 vs 14.11 to 9.58). Urbanization differences revealed higher deaths in metropolitan areas (350,860 vs.104,571), with nonmetropolitan regions experiencing a higher overall AAMR (12.32 vs 8.96). Racially, the highest number of deaths was observed in the NH White (432,894). However, NH Black had the highest AAMR (17.29). Geographically, the Northeast had the sharpest decline (AAPC: -1.99%, p < 0.001). Regarding age, the highest number of deaths occurred in the +65 age group (501,870) with a significant decline in AAMR from 72.35 in 1999 to 49.21 in 2023 (AAPC: -1.63; p = 0.004). Regarding the place of death, the majority occurred in nursing homes with 181,896 deaths (33.60%).

Conclusions Mortality from heart failure–associated cerebrovascular disease declined significantly from 1999–2023, with the steepest reductions in older adults and Northeastern states, yet persistent sex and racial disparities remain.

Authors/Disclosures
Mahmoud Tablawy, MD PRESENTER	Dr. Tablawy has nothing to disclose.
Mohamed F. Hemida Saleh	Dr. Hemida Saleh has nothing to disclose.
Alyaa Ahmed Ibrahim, MBBS (Alexandria Faculty of Medicine)	Dr. Ibrahim has nothing to disclose.
Chintha V. Sriram, MD, MBBS (IPGMER)	Dr. Sriram has nothing to disclose.
Maryam Saghir, MBBS	Miss Saghir has nothing to disclose.
Sahil Jairamani	Dr. Jairamani has nothing to disclose.
Eshal Saghir, MBBS	Miss Saghir has nothing to disclose.
Pakeezah Tabasum	Miss Jokhio has nothing to disclose.
Mohamed K. Elgendy, Sr., MBBCH	Dr. Elgendy has nothing to disclose.
Ahmed Ebrahim, MD	Dr. Ebrahim has nothing to disclose.
Amro Ali, MD	Dr. Ali has nothing to disclose.

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