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Abstract Details

Investigating the Relationship Between Daily Physical Activity and Depression in Individuals with and Without a BDNF Gene Variant: A Cross-sectional Analysis of the All of Us Database
General Neurology
P7 - Poster Session 7 (8:00 AM-9:00 AM)
7-006
This study examines the association between daily physical activity and depressive symptoms and evaluates whether the presence of a BDNF Val66Met variant moderates this relationship.
The BDNF Val66Met (rs6265) polymorphism has been linked to altered activity-dependent BDNF secretion, which may influence the antidepressant effects of physical activity. Population-based studies exploring this potential moderation effect are limited.
We conducted a cross-sectional analysis using data from the All of Us Research Program, including participants with available Fitbit step count data (≥30 days), BDNF genotype information (Met allele carriers vs. non-carriers), and Patient Health Questionnaire-9 (PHQ-9) scores. We used linear regression models to evaluate the association between average daily steps and PHQ-9 scores, with an interaction term for BDNF variant status to test moderation effects. Covariates included age, sex, race/ethnicity, income, education, and home ownership.

In a multivariable linear regression adjusting for covariates, higher daily activity was significantly associated with lower PHQ-9 score (β = -0.87, p <0.001), corresponding to a 0.24 point decrease for each additional 1,000 steps taken per day. The BDNF variant showed no independent association with PHQ-9 score (p = 0.10), and the interaction between physical activity and BDNF genotype was not significant (p = 0.59). Socioeconomic factors, including lower household income and lack of a college degree, were independently associated with higher PHQ-9 scores.
This study leveraged a large, diverse cohort to investigate the relationship between physical activity, BDNF-related gene variation, and depression. Greater daily physical activity was strongly associated with lower PHQ-9 score independent of BDNF genotype. Although the BDNF polymorphism did not moderate this effect, these findings reinforce the antidepressant benefits of regular physical activity across BDNF genotypes.
Authors/Disclosures
Dylan Letcher, Medical Student
PRESENTER 		Mr. Letcher has nothing to disclose.
Naima Rahim Miss Rahim has nothing to disclose.
Matthew Phan, Medical Student Mr. Phan has nothing to disclose.
Caitlyn Long Mrs. Long has nothing to disclose.