Abstract Details

Title Objective Life-space Mobility in Latino Aging: Cognitive, Cardiovascular, and Sociocultural Correlates in the SALUD-tech Study

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P8 - Poster Session 8 (11:45 AM-12:45 PM)

Poster/Presentation
Number 13-001

Objective This study examined life-space mobility and its correlates among Latino persons at varying risk for Alzheimer’s disease and related dementias (ADRD).

Background Life-space mobility is the degree to which people move through their environments and has been most commonly assessed via self-report. Reduced life space mobility has been linked to increased risk for ADRD. Research on objective life-space mobility is limited, particularly among Latino older adults, who experience a higher ADRD burden.

Design/Methods Participants included 176 Latino adults residing in California (age 50-70, 74% female) who completed comprehensive neuropsychological and medical evaluations. We classified participants into ADRD risk groups based on the presence or absence of mild cognitive impairment (MCI) and cardiovascular (CVD) risk. Life-space mobility was measured using smartphone GPS data collected over 7-30 days and quantified by the daily average distance traveled (total kilometers and furthest distance from home). Demographic and sociocultural variables included age, sex, years of education, paternal/maternal education, household income/household size, country of birth, years lived in the U.S., and cross-border travel.

Results Participants with CVD, regardless of cognitive status, showed significantly less life space mobility than participants without CVD. MCI alone showed minimal associations with life space once CVD status was considered. A multivariable linear regression model with predictors being demographic and sociocultural factors showed that being U.S.-born was positively related to total mobility; with no other significant associations.

Conclusions

CVD risk was strongly associated with reduced life-space mobility in this Latino cohort, indicating that GPS technology might help identify patterns of behavior that reflect biological vulnerability. Patterns of life space mobility differed among subgroups of Latinos, underscoring the need to consider Latino heterogeneity. Life space mobility, as assessed by GPS, might be an important digital biomarker of risk for developing dementia with a vascular contribution. Future longitudinal studies examining incidence of dementia will help best determine causality.

Authors/Disclosures
Andrea Mendez Colmenares, MD, PhD PRESENTER	Dr. Mendez Colmenares has nothing to disclose.
Emma G. Churchill, MA	Ms. Churchill has nothing to disclose.
Tess Filip, MA	Miss Filip has nothing to disclose.
Lizbeth Vera Murillo	Miss Vera Murillo has nothing to disclose.
Linda Gallo	Linda Gallo has nothing to disclose.
Nicole Demos	Ms. Demos has nothing to disclose.
Erin Sundermann	Erin Sundermann has received personal compensation in the range of $0-$499 for serving as a Consultant for The University of Pittsburgh. Erin Sundermann has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for University of Toronto. The institution of Erin Sundermann has received research support from California Department of Public Health. The institution of Erin Sundermann has received research support from National Institute of Aging. The institution of Erin Sundermann has received research support from Alzheimer's Association.
Douglas Galasko, MD (Dept. of Neurosciences, UCSD)	Dr. Galasko has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai. Dr. Galasko has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly, Inc. Dr. Galasko has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche Diagnostics. Dr. Galasko has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cognition THeraprutics. Dr. Galasko has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Artery Therapeutics.
Luis R. Betancourt, MA	Mr. Betancourt has nothing to disclose.
Kassandra Portillo (University of California, San Diego)	No disclosure on file
Rebecca Daly (University of California, San Diego)	No disclosure on file
Bethine Moore	Mrs. Moore has nothing to disclose.
Maria Marquine, PhD	Dr. Marquine has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Gerontology Psychological Sciences. The institution of Dr. Marquine has received research support from NIH.

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