Abstract Details

Title Impact of Hypertension on Mortality due to Vascular Dementia: Nationwide Trends from CDC-WONDER (1999–2023)

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P8 - Poster Session 8 (11:45 AM-12:45 PM)

Poster/Presentation
Number 13-005

Objective To analyze national mortality trends in vascular dementia among U.S. adults aged ≥55 years, comparing outcomes with and without hypertension to assess its impact on mortality patterns.

Background Vascular dementia, the second most common dementia subtype, arises from chronic cerebral hypoperfusion. Hypertension accelerates arteriolosclerosis and small vessel disease, leading to cognitive decline. Effective cardiovascular risk management is crucial to reduce the growing burden of vascular dementia.

Design/Methods

CDC WONDER data (1999–2023) were analyzed for U.S. adults aged ≥55 years with vascular dementia (ICD-10: F01) as the underlying cause of death along with Hypertension (I10–I15) as a multiple cause. Age-adjusted mortality rates (AAMR) were stratified by demographics and region. Joinpoint regression (JPR) estimated Annual Percent Changes (APCs) with p < 0.05 as the threshold for significance.

Results

From 1999 to 2023, the U.S. recorded 262,788 deaths due to Vascular Dementia (VD) and 58,738 deaths due to VD along with Hypertension (HTN). Higher mortality in females was observed in both conditions (VD: 63.69%, VD+HTN: 66.19%). AAMR in Vascular Dementia rose from 3.9 to 23.5, with APC of -2.83 (95% CI: -6.82 to -0.26) from 1999–2018 and 109.11 (95% CI: 71.30 to 143.50) from 2018–2021. AAMR in VD+ HTN group increased from 0.1 to 6.5 (APC: 125.26). Among Black individuals, AAMR in VD group rose from 1.3 to 23.9 (APC: 59.83; 95% CI: 43.45–342.13). In the South, mortality surged after 2016 in VD+HTN group (APC: 13.84; 95% CI: 8.69–23.2), with persistent regional and racial disparities.

Conclusions Mortality rates due to vascular dementia especially with hypertension, has increased in several vulnerable groups such as females, non-Hispanic and Black population. Notable interventions and multidisciplinary approach is required to make significant impact in mortality reduction.

Authors/Disclosures
Waqas Ahmad, MBBS PRESENTER	Mr. Ahmad has nothing to disclose.
Muhammad Saim, MBBS	Mr. Saim has nothing to disclose.
Hafiz Haseeb H. Ahsan, MBBS	Dr. Ahsan has nothing to disclose.
Jamil Numan, MD (Marshall University/ MUSOM)	Dr. Numan has nothing to disclose.
Arbaz Hassan, MBBS	Mr. Hassan has nothing to disclose.
Anum Fatima, MBBS	Dr. Fatima has nothing to disclose.
Ayesham Zahra, MBBS	Ms. Zahra has nothing to disclose.
Roshail Sajjad, MBBS	Miss Sajjad has nothing to disclose.
Aiza Shafique, MBBS	Ms. Shafique has nothing to disclose.
Atif N. Malik, MD	Dr. Malik has nothing to disclose.
Farah Shehryar, MBBS	Dr. Shehryar has nothing to disclose.
Faseeh Haider, MD, MBBS	Dr. Haider has nothing to disclose.
Syed H. Inam, MD	Dr. Inam has nothing to disclose.

��ɫ��

��ɫ��