Abstract Details

Title The Overlapping Burden of Vascular Dementia and Cerebrovascular Diseases: Alarming Mortality Trends Across 25 Years

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P8 - Poster Session 8 (11:45 AM-12:45 PM)

Poster/Presentation
Number 13-006

Objective We aim to investigate mortality trends and disparities due to vascular dementia and cerebrovascular diseases (VD-CeVD) among the geriatric population of the United States (US) for the period 2005–2023.

Background Age-related vessel damage worsens cognition and memory consolidation; meanwhile, impaired brain functioning further increases the risk of stroke. The co-occurrence of vascular dementia (VD) with cerebrovascular diseases (CeVD) is associated with increased morbidity and mortality among older adults.

Design/Methods We used CDC WONDER (2005–2023) to examine mortality due to VD-CeVD between 2005 and 2023, among older adults ≥65 years of age, using ICD-10 code: F01 (VD) and I60-I69 (CeVD). Age-adjusted and crude mortality rates (AAMRs and CMRs) were calculated, followed by Joinpoint regression (v. 5.4.0) to calculate annual percent changes (APC) and overall trends across demographics and settings.

Results

From 2005 to 2023, a total of 200,450 VD-CeVD deaths were recorded among older adults. Overall, the AAMRs rose notably from 9.38 in 2005 to 40.28 in 2023 [AAPC: 8.46; p<0.05]. Females had higher AAMRs compared to males (22.4 vs 21.13). Among racial groups, Non-Hispanic (NH) Blacks had the highest AAMR (28.53), followed by NH Whites (22.00), Hispanics (18.98), and NH Asians (15.91). Crude mortality rates were highest amongst individuals aged ≥ 85 years (107.77). Regionally, the Western region was the most affected (26.89), with metropolitan areas dominating the non-metropolitan areas (19.33 vs 16.80). State-wise AAMRs ranged between Louisiana and Oregon (7.79 to 40.32 respectively).

Conclusions Our analysis indicates that geriatric females, NH Blacks, residents of metropolitan areas of the Western US bear the highest mortality burdens from vascular dementia-related cerebrovascular disease. Future research should further explore the vulnerability and plan effective treatment patterns for high-risk individuals.

Authors/Disclosures
Javeria Javeid PRESENTER	Mrs. Javeid has nothing to disclose.
Areej Javeid	Miss Javeid has nothing to disclose.
Dinesh Kumar	Dr. Kumar has nothing to disclose.
Wajeeh Hassan, MBBS	Mr. Hassan has nothing to disclose.
Armeen Saeed, MBBS	Dr. Saeed has nothing to disclose.
Hammad Jehangir, MBBS	Dr. Jehangir has nothing to disclose.
Zain A. Nadeem (Allama Iqbal Medical College)	Mr. Nadeem has nothing to disclose.
Syed H. Inam, MD	Dr. Inam has nothing to disclose.
Usama Ahmed, MBBS	Mr. Ahmed has nothing to disclose.
Usman Faisal, MBBS	Dr. Faisal has nothing to disclose.
Edwin J. Serrano, MD (Medstar Georgetown University Hospital)	Dr. Serrano has nothing to disclose.

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