Six patients (2 males and 4 females) with a mean age of 51.3 years at diagnosis were identified with ocular syphilis. The diagnosis was confirmed in all cases by positive treponemal antibody tests, with one patient also showing a positive cerebrospinal fluid (CSF) VDRL. All patients presented with blurry vision and visual field defects (n=6), while additional symptoms included photophobia (n=1), red eye (n=1), and black spots in the visual field (n=1). Ocular involvement was bilateral in three cases. Clinical findings included uveitis in three patients, and one case each of neuroretinitis, episcleritis, and optic disc edema.

Predisposing factors included HIV status (n=1), Men who have sex with men (MSM) (n=2). All patients were treated with 14 days of intravenous penicillin therapy. 1 patient underwent a penicillin desensitization protocol.