The Get With The Guidelines™-Stroke registry at hospital site, was utilized for this study. Patients arriving within 4.5 hours of last known well time (LKWT) and discharged between 1/1/2021-12/31/2024 are included. Patients evaluated between 7pm-7am were included as stroke coverage in house was unavailable. Covariates included were age, race/ethnicity, sex, transfer status, mode of arrival, diagnosis time of arrival, and initial NIHSS. Logistic and linear regressions were used to analyze the data; results are presented as adjusted odds ratios. The independent variable was Telestroke utilization and the main dependent variables were CT to tPA administration time, arrival to tPA administration (DTN) time, and rate of tPA administration.