Abstract Details

Title Temporal Lobectomy for Temporal Lobe Epilepsy: Results After Ten Years of Follow-up

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P9 - Poster Session 9 (5:00 PM-6:00 PM)

Poster/Presentation
Number 10-003

Objective To evaluate postoperative seizure outcomes, seizure freedom, and clinical factors in patients with TLE undergoing surgical resection, over a ten-year follow-up period.

Background Temporal lobe epilepsy (TLE) is the most frequent form of focal epilepsy and a major cause of drug-resistant epilepsy (DRE). Temporal lobectomy (TL) is an established therapeutic option for selected patients who fail pharmacological treatment.

Design/Methods We conducted a descriptive, cross-sectional study of patients with TLE treated at the National Institute of Neurology and Neurosurgery. Descriptive and univariate analyses were performed using SPSS® 29. Quantitative variables were analyzed with Student’s t-test or Mann–Whitney U test, and qualitative variables with Pearson’s Chi-square or Fisher’s exact test.

Results

A total of 146 patients were included (52.7% female, mean age 52.0 years). The mean number of seizures significantly decreased from 14.36 ± 9.93 preoperatively to 2.08 ± 0.84 postoperatively (p < 0.001). Anterior temporal lobectomy was performed in 71.9%, amygdalohippocampectomy in 16.9%, parahippocampectomy in 5.6%, and lesionectomy in 5.6%. A significant reduction in antiseizure medications was observed after surgery (p < 0.001).

Seizure freedom (Engel Class I) was achieved in 66.3% at years 1–2, 67.4% at year 3, 65.1% at years 4–5, and increased to 80.2% at year 10 (p < 0.001). The association between seizure freedom and MRI lesion was not significant (p = 0.087). Amygdalohippocampectomy and temporal lobectomy were associated with lower seizure recurrence from years 4–10 (p = 0.041).

Conclusions Temporal lobe surgery provides sustained seizure freedom and significantly reduced use of ASM over ten years of follow-up, supporting its long-term efficacy in patients with drug-resistant TLE. Complete resection of the temporal lobe and amygdala also rendered better seizure control. In this study MRI findings did not significantly affect seizure outcome.

Authors/Disclosures
Juan C. Vera, Jr., Medical Student PRESENTER	Dr. Vera has nothing to disclose.
Maximiliano D. Salgado Deza	Maximiliano D. Salgado Deza has nothing to disclose.
Stefan Narvaez-Labuhn, Medical Student	Mr. Narvaez-Labuhn has nothing to disclose.
Salvador Martinez-Medina, MD	Dr. Martinez-Medina has nothing to disclose.
Jimena Gonzalez Salido, MD	Miss Gonzalez Salido has nothing to disclose.
Jimena Colado, MD	Dr. Colado has nothing to disclose.
Irving Fuentes	Mr. Fuentes has nothing to disclose.
Fernando Vasquez Lopez, MD	Dr. Vasquez Lopez has nothing to disclose.
Betsy C. Vazquez, MD	Dr. Vazquez has nothing to disclose.
Alfonso Arellano Reynoso, MD	Dr. Arellano Reynoso has nothing to disclose.
Katherin M. Plasencia Correa, MD	Dr. Plasencia Correa has nothing to disclose.
Guillermo A. Gutierrez, MD	Dr. Gutierrez has nothing to disclose.
Sergio Moreno-Jiménez, PhD	Dr. Moreno-Jiménez has nothing to disclose.
Mario Sebastian-Diaz, MD, PhD	Dr. Sebastian-Diaz has nothing to disclose.
Iris E. Martinez-Juarez, MD (Instituto Nacional de Neurología y Neurocirugía)	No disclosure on file

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