Abstract Details

Title Epilepsy Surgical Patients Report Subjective Improvement Regardless of Seizure Freedom Outcome One Year Post-op

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P9 - Poster Session 9 (5:00 PM-6:00 PM)

Poster/Presentation
Number 10-005

Objective To investigate epilepsy surgical outcomes of Drug-Resistant Epilepsy (DRE) patients and their perceived quality of life (QoL).

Background

The success of epilepsy surgery is classically measured by seizure freedom from disabling seizures. Not all patients who undergo surgery achieve this goal yet still may perceive benefit. To assess this gap, we evaluated whether QoL measures correlated with patient outcomes.

Design/Methods We completed a retrospective cohort analysis of all consecutive patients who underwent epilepsy surgery (laser ablation (LITT) and open resection) from 2022 to 2023. Surgical outcomes, post-operative Global Health Impression-Improvement Scale (GHIIS) score, and post-operative depression and anxiety scales were obtained by review of surgical conference, discharge, and one-year post-operative office visit notes. Chi-Square test of independence and Fisher’s exact test were performed.

Results 55 patients underwent surgery, with 51% (n = 28) receiving LITT and 49% (n = 27) undergoing open resections. 71% (n = 39) were seizure free (Engel I) at one-year. 56% (n=31) reported stable memory and 61% (n=34) reported stable depression scores. 74% (n = 29) of Engel I, 75% (n =6) of Engel II, and 60% (n = 3) of Engel IV patients reported their QoL on the GHIIS was “improved” or “very much improved” one year post-operatively (p=0.75). 82% (n = 23) of the LITT ablative patients and 63% (n = 17) of the open resection patients reported improvement in QoL (p = 0.11).

Conclusions Patients demonstrate a noticeable perceived benefit in QoL after one year following resective and ablative epilepsy surgery despite not always achieving seizure freedom, even those with no worthwhile improvement (Engel IV) demonstrating improved QoL. The results underscore the importance of counseling patients on probability of seizure freedom and improvement in QoL. Future evaluation will assess the stability of this improvement, and develop combined seizure freedom and QoL predictive models for epilepsy surgical outcomes.

Authors/Disclosures
Ella R. Kole PRESENTER	Miss Kole has nothing to disclose.
Wajiha Yousuf, MD	Dr. Yousuf has nothing to disclose.
Gabriela J. Bustamante, RN	Mrs. Bustamante has nothing to disclose.
Christina M. Boada, MD, MS (Hospital of the University of Pennsylvania)	Dr. Boada has nothing to disclose.
Ramya Raghupathi, MD (Hospital of University of Pennsylvania)	Dr. Raghupathi has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz .
Brian Emmert, Jr., MD (Columbia University Irving Medical Center)	Dr. Emmert has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zynx. Dr. Emmert has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Aquifer.

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