Abstract Details

Title Unmasking a Silent Surge: Mortality Trends due to Dementia in Hypertensive Older Adults: Insights from CDC-WONDER Database (1999-2023)

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P9 - Poster Session 9 (5:00 PM-6:00 PM)

Poster/Presentation
Number 12-005

Objective To assess mortality trends for dementia in hypertensive older adults in the U.S. from 1999 to 2023, highlighting the disparities across demographics and regions.

Background Dementia is a leading neurological disorder characterized by progressive cognitive decline that represents a major public health burden globally. Hypertension, a common and modifiable risk factor, has been recognized as a key contributor to the development of cognitive impairment.

Design/Methods We analyzed mortality trends for dementia (ICD-10 code: G30, F01, F03) as an underlying cause of death in hypertensive (ICD-10 code: I10-I15) elderly, as the multiple cause of death, using the CDC-WONDER database from 1999 to 2023. Age adjusted mortality rates (AAMRs) per 100,000 were calculated and categorized by demographics and region. Joinpoint regression was used to estimate Annual Percent Change (APC) and Average Annual Percent Change (AAPC) with 95% confidence intervals.

Results From 1999 to 2023, dementia recorded 651,865 deaths among hypertensive elderly patients. The overall AAMR observed a significant incline from 10.5 to 84.4 (AAPC: 8.1; 95% CI: 7 to 9.2, p<0.01). Among the subgroups of dementia, Alzheimer’s disease reported the greatest mortality (48.3%). Women observed higher overall AAMR than men from (11.7 vs. 7.4) in 1999 to (95.4 vs. 66.8) in 2023. Racially, Non-Hispanic Black population had the highest overall AAMR (1999:11.8, 2023: 93.05, AAPC: 8.1, p< 0.01). Regionally, the highest overall AAMR was recorded by the Midwest (1999: 12.1, 2023: 88.9, AAPC: 7.9, p< 0.01). Non-metropolitan areas had higher AAMR than metropolitan areas (59.5 vs 54.8). State-level AAMRs ranged from 48.08 (Connecticut) to 188.2 (Oklahoma) in 2023.

Conclusions This nationwide analysis spanning from 1999 to 2023, demonstrated a marked rise in mortality rate due to dementia in hypertensive older adults. The escalating prevalence and mortality burden, underscore the urgent need for enhanced surveillance, preventive strategies, and targeted therapeutic interventions.

Authors/Disclosures
Shayan Marsia, MBBS PRESENTER	Dr. Marsia has nothing to disclose.
Maryam Saghir, MBBS	Miss Saghir has nothing to disclose.
Muhammad Hamza Shoaib, MBBS	Mr. Shoaib has nothing to disclose.
Eshal Saghir, MBBS	Miss Saghir has nothing to disclose.
Hozefa Mateen, MBBS	Mr. Mateen has nothing to disclose.
Muhammad Affan, MD (University of Minnesota)	Dr. Affan has nothing to disclose.
Hassan Khanzada, DO (Corewell Health Hospitals)	Dr. Khanzada has nothing to disclose.
Ryan Bean, DO	Dr. Bean has nothing to disclose.

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