This study examines long-term mortality trends and demographic disparities in Alzheimer disease and cardiac arrest related deaths in the United States from 1999 to 2024.

Cardiac arrest is a frequent terminal event in Alzheimer disease, yet  mortality trends capturing this overlap remain underexplored. As Alzheimer's prevalence grows with aging populations, understanding associated mortality patterns is critical for prevention and care planning.

We analyzed death certificate data from the CDC WONDER database for adults ≥65 years using ICD-10 codes for Alzheimer's disease (G30.0, G30.1, G30.8, G30.9) and cardiac arrest (I46.0). Age-adjusted mortality rates (AAMRs) per 100,000 persons with 95% confidence intervals (CI) were standardized to the 2000 US population. Temporal patterns were assessed using joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC), stratified by sex, race, census region, urbanisation, and state.

Alzheimer disease with cardiac arrest related mortality shows modest overall decline, but marked disparities persist by sex, race, geography, and care setting. Targeted prevention and resource allocation are  needed to reduce inequities and improve end-of-life outcomes.