To study the mortality trends of adults with Alzheimer's disease and mental disorders from 1999 to 2024.

Alzheimer’s disease (AD) and mental disorders (MD) are leading causes of mortality in the United States. Examining their long-term mortality patterns is essential to understanding disease progression and public health impact. 

We analyzed the retrospective data using the CDC WONDER database from 1999 to 204 for adults aged greater than >65 up to 85+. We calculate the annual percent change( APC) and  Average annual percent change (AAPCs) per 100,000 population with a 95% confidence interval (CI) using joinpoint regression. A p-value less than 0.005 will be significant.

From 1999 to 2024, a total of 287,276 deaths were calculated, with the APC value decreasing from 1.73 to 1.40, with overall age-adjusted mortality rates ( AAMRs) increasing from 12.4 to 39.3, with most deaths reported in Nursing homes/long-term care. Analysis shows higher mortality in females with an APC value of 42.5; region-wise shows an increase in the south with an APC of 47, with a p-value < 0.005. In the race, whites show the highest AAMRs of 25.7, compared with other races, and Urban areas show the highest 9.95 APC value compared with rural areas. In age-wise analysis, the highest deaths are in the 85+ age group, with a crude rate of 180.5, with Washington having an AMR value of 51.9.

Although the annual percent change (APC) declined, overall mortality from Alzheimer’s disease and mental disorders significantly increased from 1999 to 2024. The burden was greater among females, Whites, and those in southern and urban regions. These results highlight the growing public health concern and the need for targeted awareness, early intervention, and equitable healthcare measures to reduce disparities.