Abstract Details

Title Sleep and Neuropathic Disorders: Insights into Risk and Comorbidity Patterns Using the All of Us Research Program

Topic Sleep

Presentation(s) P9 - Poster Session 9 (5:00 PM-6:00 PM)

Poster/Presentation
Number 14-004

Objective

Determine whether sleep disorders correlate with a higher risk of developing neuropathic disorders, neuropathy, and greater neuropathic symptom severity.

Background

Neuropathic pain, commonly due to peripheral neuropathy and lumbar radiculopathy (LR), is a leading cause of disability, affecting approximately 7-10% of the adult population. While LR is often due to degenerative spine disease, 25-46% of peripheral neuropathy cases remain idiopathic. Sleep disorders, including insomnia and obstructive sleep apnea (OSA), impact millions and are linked to worse neuropathic pain and inflammation, yet population-level studies on this risk remain limited.

Design/Methods We reviewed All of Us Registered Tier Dataset v8, including patients with neuropathy diagnosed at least 7 days after a sleep disorder diagnosis (“Cohort 1”) and neuropathy-only patients (“Cohort 2”). Exclusions included those deceased, history of stroke, hypothyroidism, HIV/AIDS, alcohol use disorder, chemotoxicity, or hematologic disorders. Analyses were conducted using RStudio.

Results A total of 27,444 participants were included in Cohort 1, and 73,415 in Cohort 2. LR following insomnia was the most common neuropathic disorder among patients with sleep disorders, occurring in 4.9% of cases. Insomnia was associated with a 15.6% higher risk of polyneuropathy (RR 1.16, 95% CI 1.04–1.29), while OSA conferred a 2.6% higher risk of LR (RR 1.03, 95% CI 0.95–1.11). Cohort 1 participants were older (63.9 vs. 62.02 years) and had higher BMI (33.12 vs. 31.15). Pain scores were elevated in Cohort 1 (4.36 vs. 3.92, p < 0.001), and mild-to-moderate fatigue was reported in both groups (p < 0.001).

Conclusions Insomnia and OSA were associated with a higher risk of specific neuropathic disorders, particularly polyneuropathy and lumbar radiculopathy, respectively. Older age, higher BMI, and elevated pain scores may further characterize populations at greater risk, highlighting the need for targeted management strategies in patients with sleep disorders.

Authors/Disclosures
John N. Abdallah, Medical Student PRESENTER	Mr. Abdallah has nothing to disclose.
Amaan S. Virdi	Mr. Virdi has nothing to disclose.
Will Potratz	Mr. Potratz has nothing to disclose.
Arth Thaker	No disclosure on file
Frank M. Scali, MD	Dr. Scali has nothing to disclose.

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