Abstract Details

Title Association Between Obstructive Sleep Apnea and Autonomic Symptoms in Parkinson’s Disease: A Cross-sectional Analysis

Topic Movement Disorders

Presentation(s) P9 - Poster Session 9 (5:00 PM-6:00 PM)

Poster/Presentation
Number 17-002

Objective To examine the association between obstructive sleep apnea (OSA) and autonomic burden in patients with Parkinson’s disease (PD)

Background Autonomic dysfunction is a common non-motor feature of PD that significantly impacts quality of life. Although OSA is prevalent in PD and has been associated with worse motor and cognitive outcomes, its relationship with autonomic dysfunction particularly across specific autonomic domains remains undescribed.

Design/Methods A cross-sectional study was conducted using data from the Parkinson’s Progression Markers Initiative (PPMI; www.ppmi-info.org). Approximately 3,596 patients with complete data were included after excluding those lacking sufficient information on SCOPA-AUT or OSA diagnosis. OSA was defined based on a documented clinical diagnosis. Autonomic dysfunction was assessed using the SCOPA-AUT scale, with domain-specific scores (Gastrointestinal, Urinary, Cardiovascular, Thermoregulatory, Pupillomotor, Sexual, and Total). Multivariable linear regression models were performed, adjusting for age, sex, motor severity (UPDRS-III), and cognition (MoCA). False discovery rate (FDR) correction was applied for multiple comparisons. Additionally, a post hoc analysis was conducted to explore OSA*sex interactions, and non-parametric tests (Mann–Whitney U) were used to confirm distributional differences between groups.

Results OSA was significantly associated with higher total SCOPA-AUT scores (β = 1.11; 95% CI: 0.7–1.5; p < 0.001; FDR-corrected p = 0.00024), as well as with specific autonomic domains: Gastrointestinal, Urinary, Pupillomotor, and Sexual. Sex interactions were significant across several domains, indicating a stronger association in males.

Conclusions

In this cross-sectional analysis, we identified an association between OSA and greater autonomic burden in PD, with heterogeneity across autonomic domains and sex. Longitudinal studies are needed to clarify the directionality of this relationship and to support the development of an emerging line of research in Parkinson’s disease.

Authors/Disclosures
Francisco A. Luna-Rangel, MD, BS PRESENTER	Dr. Luna-Rangel has nothing to disclose.
Brenda Gonzalez, Jr., MD	Dr. Gonzalez has nothing to disclose.
Karen I. Pozo, MBBS	Dr. Pozo has nothing to disclose.
Erick Alejandro Barajas Llamas, MD	Dr. Barajas Llamas has nothing to disclose.
Walter F. Torres II, MD	Dr. Torres has nothing to disclose.
Karla Boeta-Lopez, MD (Baylor Scott and White)	Dr. Boeta-Lopez has nothing to disclose.
Elly Robles, PhD	Dr. Robles has nothing to disclose.
Daniel Rebolledo, Jr., MD (Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán)	Dr. Rebolledo has nothing to disclose.
Daniel Martinez-Ramirez, MD (Oncare)	Dr. Martinez-Ramirez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB Mexico. Dr. Martinez-Ramirez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbott Mexico.

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