MG is chronic autoimmune disorder with varying severity, and current assessment methods do not provide cost effective, easily obtainable biomarkers that determines disease activity. The LAR score which indicates both muscle damage and immune function, has demonstrated prognostic significance in some systemic diseases but not studied in MG.

This case control study included 65 patients with MG and 65 healthy controls. The disease severity was assessed according to Myasthenia Gravis Activities of Daily Living Scale (MG-ADL). Patients with score of 0 to 15 were grouped into mild to moderate disease and with score of 16 to 24 were grouped into severe disease. LAR score was calculated and compared among disease cases and healthy control groups. The multivariate logistic regression analysis of variables was used to determine the contribution of variance in MG disease severity. Receiver operating characteristics (ROC) curve was plotted to assess the role of LAR as risk factor for MG severity. Statistical significance was taken as P < 0.05.