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2020 Annual Meeting | S4 - Aging and Dementia: Risk Factors and Genetics

Sunday 04/26/20
01:00 PM - 03:00 PM Add To Calendar
This program will be presented both in-person and online
This program is not expected to be available in the meeting's On Demand product.
Scientific Platform Session
Richard J. Caselli, MD, FAAN, Sudha Seshadri, MD, FAAN
Aging, Dementia, and Behavioral Neurology
2.00 CME credits
Event Timeline
01:00 PM - 01:12 PM Abstract 001 - Neuropsychological Decline Up to 20 Years Before Incident Mild Cognitive Impairment
Richard J. Caselli, MD, FAAN
01:12 PM - 01:24 PM Abstract 002 - Neurodegenerative Outcomes Following Diagnosis of REM Sleep Behavior Disorder or Isolated REM Sleep Without Atonia
Carol Swetlik, MD
01:24 PM - 01:36 PM Abstract 003 - Transcriptome Analysis of Single Nucleus RNA-seq from Alzheimer Disease APOE4 Carrier Brains in African American (AA) and Non-Hispanic Whites (NHW) Reveals Differences in APOE Expression
01:36 PM - 01:48 PM Abstract 004 - Cardiovascular Health Across Young Adulthood, Cerebral Autoregulation, and Cognitive Function in Midlife
Meghana Shownkeen, MD
01:48 PM - 02:00 PM Abstract 005 - Evidence of a Causal Association Between Cancer and Alzheimer’s Disease: A Mendelian Randomization Analysis
Sahba Seddighi
02:00 PM - 02:12 PM Abstract 006 - Using the Lens of Local Ancestry to Focus Risk in Alzheimer Disease
Farid Rajabli, PhD
02:12 PM - 02:24 PM Abstract 007 - Vesicular Transport Related Genes Impact Age of Onset in Alzheimer’s Disease (AD)
Jagan Pillai, MD, PhD, FAAN
02:24 PM - 02:36 PM Abstract 008 - In a Large Belgian AD Cohort Loss of ABCA7 Mutations Are Associated with Alzheimer’s Disease and Cerebral Amyloid Angiopathy.
Elisabeth Hendrickx Van de Craen, MD
02:36 PM - 02:48 PM Abstract 009 - Genome-wide Association Study of Tau PET in the Mayo Clinic Study of Aging
Vijay K. Ramanan, MD, PhD
02:48 PM - 03:00 PM Abstract 010 - Genome-wide Association Study Identifies Variants in FAM171A2 Associated with Cerebrospinal Fluid Progranulin Levels and Neurodegenerative Diseases
Wei Xu
Faculty Disclosures
Richard J. Caselli, MD, FAAN The institution of Dr. Caselli has received research support from NIA. The institution of Dr. Caselli has received research support from State of Arizona.
Sudha Seshadri, MD, FAAN Dr. Seshadri has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Seshadri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Seshadri has received research support from NIH. The institution of Dr. Seshadri has received research support from Alzheimer Association.
Nancy R. Foldvary-Schaefer, DO, FAAN Dr. Foldvary-Schaefer has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz. The institution of Dr. Foldvary-Schaefer has received research support from Jazz. The institution of Dr. Foldvary-Schaefer has received research support from Suven. The institution of Dr. Foldvary-Schaefer has received research support from Takeda. Dr. Foldvary-Schaefer has received publishing royalties from a publication relating to health care. Dr. Foldvary-Schaefer has received publishing royalties from a publication relating to health care.
Jeffery Vance, MD, PhD Dr. Vance has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for neurology genetics.
Jagan Pillai, MD, PhD, FAAN Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Springer Nature. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Current Treatment Options in Neurology. The institution of Dr. Pillai has received research support from Alzheimer's Association. The institution of Dr. Pillai has received research support from Keep Memory Alive Foundation . The institution of Dr. Pillai has received research support from NIA. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Reviewer with DOD. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Reviewer with RGC Hong kong.
M. M. Mesulam, MD, FAAN No disclosure on file
Jonathan Haines, MD No disclosure on file
No disclosure on file
James B. Leverenz, MD, FAAN Dr. Leverenz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia. Dr. Leverenz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Leverenz has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai.
Jonathan Graff-Radford, MD, FAAN Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NINDS/NIH. Dr. Graff-Radford has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Graff-Radford has received research support from NIH. The institution of Dr. Graff-Radford has received research support from Eisai. The institution of Dr. Graff-Radford has received research support from Cognition therapeutics.
Jean-Jacques Martin, MD No disclosure on file
Ronald C. Petersen, MD, PhD, FAAN Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly and Co.. Dr. Petersen has received personal compensation in the range of $0-$499 for serving as a Consultant for Eisai, Inc.. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Nordisk. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has a non-compensated relationship as a Board of Directors with American Brain Foundation that is relevant to AAN interests or activities.
Patrick Cras, MD, PhD The institution of Dr. Cras has received research support from Belgian Fund for Scientific Research. Dr. Cras has received personal compensation in the range of $0-$499 for serving as a member with National Bioethics Committee.
Jin-Tai Yu No disclosure on file
William K. Scott, MD No disclosure on file
Christine Van Broeckhoven, PhD Dr. Van Broeckhoven has nothing to disclose.
Peter P. De Deyn, MD, PhD Dr. De Deyn has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for elsevier.
Michelle M. Mielke, PhD Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LabCorp. Dr. Mielke has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Siemens Healthineers. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sunbird Bio. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Mielke has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novo Nordisk.
David S. Knopman, MD, FAAN Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.
Clifford R. Jack, Jr., MD The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic.
Owen A. Ross, PhD Dr. Ross has nothing to disclose.
Sebastiaan Engelborghs, MD, PhD No disclosure on file
Lan Tan No disclosure on file
Scott Przybelski Scott Przybelski has nothing to disclose.
Prashanthi Vemuri, PhD The institution of Dr. Vemuri has received research support from NIH.
Anne Sieben, MD Dr. Sieben has nothing to disclose.
Val J. Lowe, MD Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals.
Gary W. Beecham, PhD The institution of Dr. Beecham has received research support from NIH. The institution of an immediate family member of Dr. Beecham has received research support from NIH.
Patrice Whitehead No disclosure on file
Carlos Rodriguez, MD Dr. Rodriguez has nothing to disclose.
Eric M. Reiman, MD Dr. Reiman has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Denali, Green Valley, Zinfandel, and Takeda. Dr. Reiman has received stock or an ownership interest from Alkahest, Alzheon, Aural Analytics, Denali, and United Neuroscience.. Dr. Reiman has received intellectual property interests from a discovery or technology relating to health care. Dr. Reiman has received personal compensation in the range of $500-$4,999 for serving as a Member, National Advisory Council on Aging (NACA) with NIA.
Robert Unger No disclosure on file
Margaret A. Pericak-Vance, PhD Dr. Pericak-Vance has nothing to disclose.
Carol Swetlik, MD An immediate family member of Dr. Swetlik has received personal compensation for serving as an employee of Pfizer. Dr. Swetlik has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genetech. Dr. Swetlik has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen.
Sandra Weintraub, PhD, FAAN Dr. Weintraub has nothing to disclose.
Farzaneh A. Sorond, MD, PhD Dr. Sorond has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Dr. Sorond has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Stryker. The institution of Dr. Sorond has received research support from NIH.
Dona Locke, PhD Dr. Locke has nothing to disclose.
Farid Rajabli, PhD Farid Rajabli has nothing to disclose.
Kristine Yaffe, MD Dr. Yaffe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Yaffe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Quintiles. Dr. Yaffe has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Alector. The institution of Dr. Yaffe has received research support from NIH. The institution of Dr. Yaffe has received research support from DOD. The institution of Dr. Yaffe has received research support from Veterans Affairs.
Bryan K. Woodruff, MD The institution of Dr. Woodruff has received research support from National Institute on Aging.
Simin Mahinrad, MD, PhD No disclosure on file
Meghana Shownkeen, MD No disclosure on file
Anthony J. Griswold, PhD Dr. Griswold has received research support from National Institutes of Health.
Changiz Geula, PhD No disclosure on file
Wei Xu No disclosure on file
Vijay K. Ramanan, MD, PhD The institution of Dr. Ramanan has received research support from the National Institutes of Health. The institution of Dr. Ramanan has received research support from the Mangurian Foundation for Lewy Body Disease Research. The institution of Dr. Ramanan has received research support from as part of clinical trials sponsored by the Alzheimer's Association, Eisai, the Alzheimer's Treatment and Research Institute at USC, and Transposon Therapeutics, Inc.. The institution of Dr. Ramanan has received research support from Medscape. The institution of Dr. Ramanan has received research support from Expert Perspectives in Medicine. Dr. Ramanan has received personal compensation in the range of $500-$4,999 for serving as a Conference Speaker/Organizer (Honoraria) with AANI.
Bernard J. Hanseeuw, MD, PhD Dr. Hanseeuw has nothing to disclose.
Alexander Houck, MD Dr. Houck has nothing to disclose.
Tobi Van den Bossche No disclosure on file
Sahba Seddighi No disclosure on file
Elisabeth Hendrickx Van de Craen, MD Dr. Hendrickx Van de Craen has nothing to disclose.
Sheela Raghavan No disclosure on file