2023 Annual Meeting | S42 - Movement Disorders: Genetics and Risk Modifiers

Date Wednesday 04/26/23

Time 03:30 PM - 05:30 PM EST Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Scientific Platform Session

Moderator(s) Harini Sarva, MD, FAAN, Marta San Luciano, MD, FAAN

Topic(s) Movement Disorders

Learning Objectives A group of abstracts covering a similar topic presented in an oral format. Presentations are eight minutes in length with four minutes for question and answer with the author.

CME Available 2.00 CME credits

Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Non-neurologist, Advanced Practice Provider, Neurohospitalist, Medical Student

Teaching Styles Didactic

Event Timeline
03:30 PM - 03:42 PM EST	Abstract	001 - Identification of candidate Parkinson’s disease predisposition genes in high-risk pedigrees Paolo M. Moretti, MD
03:42 PM - 03:54 PM EST	Abstract	002 - Frequency of Known Genetic Variants for Parkinson’s Disease in the PD GENEration Study Cohort James Beck, PhD
03:54 PM - 04:06 PM EST	Abstract	003 - Understanding how GBA mutations influence Parkinson’s disease progression Arnav Khera
04:06 PM - 04:18 PM EST	Abstract	004 - Expanding the genotype-phenotype landscape of PDE10A- associated movement disorders Ali H. Abusrair, MD
04:18 PM - 04:30 PM EST	Abstract	005 - Correlation Between Motor Progression and Structural Connectivity in GBA, LRRK2, and sporadic Parkinson’s Disease Cherry Yu, MD
04:30 PM - 04:42 PM EST	Abstract	006 - Proteomic Signatures Associated with Genetic and Clinical Subtypes of Parkinson’s Disease Mei-Yu Lai
04:42 PM - 04:54 PM EST	Abstract	007 - Treatment of High Blood Pressure is associated with a Reduced Incidence of Parkinson’s disease Trond Riise
04:54 PM - 05:06 PM EST	Abstract	008 - Low Dose Carbon Monoxide Is Neuroprotective in Models of Parkinson's Disease Stephen N. Gomperts, MD, PhD, FAAN
05:06 PM - 05:18 PM EST	Abstract	009 - Assessing Sex Differences in Individuals with Tourette Syndrome and Persistent Motor or Vocal Tic Disorder Marisela E. Dy-Hollins, MD, MSCR, FAAN
05:18 PM - 05:30 PM EST	Abstract	010 - Conversion Rate of Essential Tremor to Essential Tremor-Parkinson’s Disease: Data from a Prospective, Longitudinal Study Elan D. Louis, MD, MS, FAAN

Faculty Disclosures
Saeed A. Bohlega, MD	No disclosure on file
Karen S. Marder, MD, MPH, FAAN	Dr. Marder has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Marder has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Marder has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Parkinson's Foundation . Dr. Marder has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for CHDI. Dr. Marder has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for PTC therapeutics. Dr. Marder has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer LTD. The institution of Dr. Marder has received research support from Vaccinex. The institution of Dr. Marder has received research support from Genentech. The institution of Dr. Marder has received research support from Triplet Therapeutics. The institution of Dr. Marder has received research support from Prilenia.
Martha A. Nance, MD	Dr. Nance has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Voyager. Dr. Nance has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ROche. Dr. Nance has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Nance has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Uniqure. An immediate family member of Dr. Nance has received stock or an ownership interest from Fresca. The institution of Dr. Nance has received research support from HDSA. The institution of Dr. Nance has received research support from Parkinson Foundation. Dr. Nance has received research support from Parkinson Foundation. The institution of Dr. Nance has received research support from Neuraly. Dr. Nance has received personal compensation in the range of $500-$4,999 for serving as a speaker with AAN.
Stefan M. Pulst, MD, FAAN	Dr. Pulst has received personal compensation in the range of $500-$4,999 for serving as a Consultant for venrock. Dr. Pulst has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arrowhead. Dr. Pulst has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Leverna. Dr. Pulst has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AAN. Dr. Pulst has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Leninthal LLC. The institution of Dr. Pulst has received research support from NINDS. Dr. Pulst has received intellectual property interests from a discovery or technology relating to health care.
Elan D. Louis, MD, MS, FAAN	Dr. Louis has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wolters Kluwer - Merritt's Textbook of Neurology. Dr. Louis has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Legal Firm. The institution of Dr. Louis has received research support from National Institutes of Health. Dr. Louis has received publishing royalties from a publication relating to health care. Dr. Louis has a non-compensated relationship as a Board of Directors with International Essential Tremor Foundation that is relevant to AAN interests or activities. Dr. Louis has a non-compensated relationship as a Medical Advisory Board with HopeNET that is relevant to AAN interests or activities.
Michael Schwarzschild, MD, PhD	The institution of Dr. Schwarzschild has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bial Biotech (indirectly, as a service of the Parkinson Study Group service). The institution of Dr. Schwarzschild has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen (indirectly, as a service of the Parkinson Study Group service). The institution of Dr. Schwarzschild has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB (indirectly, as a service of the Parkinson Study Group service). Dr. Schwarzschild has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. The institution of Dr. Schwarzschild has received research support from NIH. The institution of Dr. Schwarzschild has received research support from Parkinson's Foundation. The institution of Dr. Schwarzschild has received research support from Michael J Fox Foundation. The institution of Dr. Schwarzschild has received research support from Farmer Family Foundation. Dr. Schwarzschild has a non-compensated relationship as a Chair, Executive Committee with the Parkinson Study Group that is relevant to AAN interests or activities.
Tanya Simuni, MD, FAAN	Dr. Simuni has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for cadia, AcureX, Adamas, AskBio, Amneal, Blue Rock Therapeutics, Caraway Therapeutics, Critical Path for Parkinson's Consortium (CPP), Denali, Michael J Fox Foundation, Neuroderm, Sanofi, Sinopia, Roche, Takeda and Vanqua Bio. Dr. Simuni has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for of Koneksa, Neuroderm, Sanofi, UCB, AcureX, Adamas, AskBio, Biohaven, Denali, GAIN, Neuron23 and Roche. Dr. Simuni has received research support from Amneal, Biogen, Neuroderm, Prevail, Roche, and UCB and an investigator for NINDS, MJFF, Parkinson's Foundation.
Nutan Sharma, MD, PhD, FAAN	Dr. Sharma has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. Dr. Sharma has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. Dr. Sharma has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Cambridge Expert Witness. The institution of Dr. Sharma has received research support from NIH.
Clemens R. Scherzer, MD	Dr. Scherzer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. The institution of Dr. Scherzer has received research support from NIH. The institution of Dr. Scherzer has received research support from Michael J. Fox Foundation. The institution of Dr. Scherzer has received research support from American Parkinson's Disease Association. Dr. Scherzer has received intellectual property interests from a discovery or technology relating to health care.
Paolo M. Moretti, MD	The institution of Dr. Moretti has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie, Inc. The institution of an immediate family member of Dr. Moretti has received research support from NIH. The institution of an immediate family member of Dr. Moretti has received research support from VHA. The institution of an immediate family member of Dr. Moretti has received research support from DOD.
Karla P. Figueroa	Ms. Figueroa has nothing to disclose.
Tatiana Foroud, PhD	The institution of Dr. Foroud has received research support from NIH. The institution of Dr. Foroud has received research support from Michael J. Fox Foundation. The institution of Dr. Foroud has received research support from Parkinson Foundation. Dr. Foroud has received personal compensation in the range of $500-$4,999 for serving as a Member of an Advisory Committee with Mayo Clinic, University of Pennsylvania, Allen Institute, Mt. Sinai, Van Andel Institute.
Anne Marie A. Wills, MD	Dr. Wills has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Accordant, a CVS/Caremark company. Dr. Wills has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi/Genzyme. The institution of Dr. Wills has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ono Pharmaceuticals. The institution of Dr. Wills has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx. Dr. Wills has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Parkinson's Foundation. The institution of Dr. Wills has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amylyx Pharmaceuticals. The institution of Dr. Wills has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ono Pharmaceuticals. The institution of Dr. Wills has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche/Genentech. The institution of Dr. Wills has received research support from Parkinson's Foundation. The institution of Dr. Wills has received research support from Biogen. The institution of Dr. Wills has received research support from Roche/Genentech. The institution of Dr. Wills has received research support from BioSensics.
Stephen N. Gomperts, MD, PhD, FAAN	Dr. Gomperts has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EIP. Dr. Gomperts has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cowen. Dr. Gomperts has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bob's Last Stand. Dr. Gomperts has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Focus Boston. Dr. Gomperts has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Expert connect. Dr. Gomperts has received personal compensation in the range of $0-$499 for serving as a Consultant for Mosaic. Dr. Gomperts has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jannsen. The institution of Dr. Gomperts has received research support from NIH. The institution of Dr. Gomperts has received research support from LBDA. The institution of Dr. Gomperts has received research support from DOD/CDMRP. The institution of Dr. Gomperts has received research support from FFFPRI. The institution of Dr. Gomperts has received research support from NIH. The institution of Dr. Gomperts has received research support from MJFF. The institution of Dr. Gomperts has received research support from NIH. The institution of Dr. Gomperts has received research support from NIH. The institution of Dr. Gomperts has received research support from MJFF. The institution of Dr. Gomperts has received research support from NIH. The institution of Dr. Gomperts has received research support from NIH. Dr. Gomperts has received intellectual property interests from a discovery or technology relating to health care.
Jeremiah M. Scharf, MD, PhD	The institution of Dr. Scharf has received research support from the TLC Foundation for Body-Focused Repetitive Behaviors. Dr. Scharf has received personal compensation in the range of $500-$4,999 for serving as a Speaker for a TAA/CDC Family Day Symposium with the Tourette Association of America. Dr. Scharf has a non-compensated relationship as a Scientific Advisory Board Member with the Tourette Association of America that is relevant to AAN interests or activities.
Marta San Luciano, MD, FAAN	Dr. San Luciano has received research support from NIH (NINDS).
Roy Alcalay, MD	Dr. Alcalay has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genzyme/Sanofi. Dr. Alcalay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Alcalay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Gain Therapeutics. Dr. Alcalay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vanqua Bio. Dr. Alcalay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Takeda. Dr. Alcalay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biohaven. Dr. Alcalay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Capsida. Dr. Alcalay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Servier. The institution of Dr. Alcalay has received research support from Michael J. Fox Foundation. The institution of Dr. Alcalay has received research support from Parkinson's Foundation. The institution of Dr. Alcalay has received research support from Silverstein Foundation. Dr. Alcalay has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant with Parkinson's Foundation.
Stephanie Cosentino, PhD	Dr. Cosentino has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Association for Frontotemporal Dementia. Dr. Cosentino has received personal compensation in the range of $500-$4,999 for serving as a Consultant for SAGE Pharmaceuticals.
Christine Cooper, MD	Dr. Cooper has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acorda. Dr. Cooper has received research support from NIH. Dr. Cooper has received research support from Ralph H Johnson VA Medical Center.
Marie Y. Davis, MD, PhD	Dr. Davis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Davis has received research support from NIH NINDS. The institution of Dr. Davis has received research support from University of Washington Institute for Stem Cell and Regenerative Medicine. The institution of Dr. Davis has received research support from VA BLRD. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as a study section grant reviewer with NIH. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with Parkinson's Foundation.
Trond Riise	Trond Riise has nothing to disclose.
Harini Sarva, MD, FAAN	The institution of Dr. Sarva has received research support from Insightec. The institution of Dr. Sarva has received research support from NeuroNext. The institution of Dr. Sarva has received research support from Neuroderm. The institution of Dr. Sarva has received research support from Sun Pharma. The institution of Dr. Sarva has received research support from Prevail. The institution of Dr. Sarva has received research support from Bluerock Therapeutics. The institution of Dr. Sarva has received research support from Biogen. The institution of Dr. Sarva has received research support from Roche. The institution of Dr. Sarva has received research support from National Institute of Aging. The institution of Dr. Sarva has received research support from Michael J Fox Foundation. The institution of Dr. Sarva has received research support from Novo Nordisk. The institution of Dr. Sarva has received research support from Bukwang. The institution of Dr. Sarva has received research support from Bial. The institution of Dr. Sarva has received research support from Cerevance. The institution of Dr. Sarva has received research support from UCB. The institution of Dr. Sarva has received research support from MeiraGTX.
	No disclosure on file
Carol Mathews	The institution of Carol Mathews has received research support from NIH. Carol Mathews has received publishing royalties from a publication relating to health care.
James Beck, PhD	Dr. Beck has received personal compensation for serving as an employee of Parkinson's Foundation. The institution of Dr. Beck has received research support from NIH, MJFF.
Salma M. AlQahtani, MD	Dr. Al Qahtani has nothing to disclose.
Marisela E. Dy-Hollins, MD, MSCR, FAAN	The institution of Dr. Dy-Hollins has received research support from CNCDP-K12.
Federico J. Rodriguez-Porcel, MD	Dr. Rodriguez-Porcel has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BioVie. Dr. Rodriguez-Porcel has received personal compensation in the range of $500-$4,999 for serving as a Consultant for WCG. Dr. Rodriguez-Porcel has received research support from NIH. Dr. Rodriguez-Porcel has received publishing royalties from a publication relating to health care.
Cherry Yu, MD	Dr. Yu has nothing to disclose.
Marianna Cortese, MD, PhD	Dr. Cortese has received personal compensation in the range of $500-$4,999 for serving as a speaker at educational event with Roche.
Ali H. Abusrair, MD	Dr. Abusrair has nothing to disclose.
Kjetil Bjornevik, MD, PhD	The institution of Dr. Bjornevik has received research support from Michael J. Fox Foundation. The institution of Dr. Bjornevik has received research support from National Multiple Sclerosis Society. The institution of Dr. Bjornevik has received research support from Department of Defense.
Niccolo Mencacci, MD, PhD	The institution of Dr. Mencacci has received research support from NIH.
Musab Zorlu, MD	Dr. Zorlu has nothing to disclose.
Jennifer Verbrugge	Jennifer Verbrugge has nothing to disclose.
Divya Palanisamy, MD	Dr. Palanisamy has nothing to disclose.
Arnav Khera	Mr. Khera has nothing to disclose.
Raja E. Estes, BS	Ms. Estes has nothing to disclose.
Julia A. Tuominen, MPsych	Miss Tuominen has nothing to disclose.
Alessandro Dotti	Mr. Dotti has nothing to disclose.
Mei-Yu Lai	Ms. Lai has nothing to disclose.
Lori Chibnik	No disclosure on file
Leo Pallanck	No disclosure on file
Selina Yu	Selina Yu has nothing to disclose.
Jessica Young	No disclosure on file
Sarah Fish	Sarah Fish has nothing to disclose.
Diane Berry	No disclosure on file
Ali Ghanem	No disclosure on file

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