2024 Annual Meeting | S37 - Emerging Therapies in Child Neurology

Date Wednesday 04/17/24

Time 03:30 PM - 05:30 PM MDT Add To Calendar

Session Format This program will be presented in-person only

On Demand This program will be available in the meeting's On Demand product.

Event Type Scientific Platform Session

Moderator(s) Ariel M. Lyons-Warren, MD, PhD, Jessica Carpenter, MD

Topic(s) Child Neurology and Developmental Neurology

Learning Objectives A group of abstracts covering a similar topic will be presented in an eight-minute oral format followed by four minutes of question and answer with the author.

CME Available 2.00 CME credits

Program Evaluations

Event Timeline
03:30 PM - 03:42 PM MDT	Abstract	001 - Dietary Vitamin D Supplementation Mitigates Neuroinflammation in a Novel Mouse Model of Cerebral Demyelinating Adrenoleukodystrophy Keith Van Haren, MD
03:54 PM - 04:06 PM MDT	Abstract	003 - Trofinetide for the Treatment of Girls Aged Two to Four Years with Rett Syndrome: Final Results from the Open-label DAFFODIL Study Alan K. Percy, MD, FAAN
04:06 PM - 04:18 PM MDT	Abstract	004 - Genotype-phenotype Correlations and Sex Differences in ZC4H2-associated Rare Disorder (ZARD): Results from the ZARD Natural History Study Sydney Peters
04:18 PM - 04:30 PM MDT	Abstract	005 - Midazolam Versus Ketamine as the First-line Continuous Infusion for Status Epilepticus in Children with Congenital Heart Disease Sam Javadian
04:30 PM - 04:42 PM MDT	Abstract	006 - RAINBOWFISH: Primary Efficacy and Safety Data in Risdiplam-treated Infants with Presymptomatic Spinal Muscular Atrophy (SMA) Laurent Servais
04:42 PM - 04:54 PM MDT	Abstract	007 - Mechanisms of Neurodegeneration and Mini-gene Therapeutic Approach for Charcot-Marie-Tooth Disease Type 4B3 Elizabeth H. Jacobs
04:54 PM - 05:06 PM MDT	Abstract	008 - Assessing Experiences with Trofinetide for Rett Syndrome: Interviews with Caregivers of Patients in Open-label Studies Kathie M. Bishop, PhD
05:06 PM - 05:18 PM MDT	Abstract	009 - Neuroimaging Abnormalities Predict Immunotherapy Responsiveness in Down Syndrome Regression Disorder Jonathan Santoro, MD
05:18 PM - 05:30 PM MDT	Abstract	010 - In-vitro Efficacy and In-vivo Biodistribution Studies of an Antisense Oligonucleotide Targeting Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation Manouchehr Amanat

Faculty Disclosures
Richard S. Finkel, MD, FAAN	Dr. Finkel has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AveXis. Dr. Finkel has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Finkel has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Catabasis. Dr. Finkel has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Capricor. Dr. Finkel has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ReveraGen. Dr. Finkel has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Finkel has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Scholar Rock. Dr. Finkel has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. The institution of Dr. Finkel has received research support from AveXis. The institution of Dr. Finkel has received research support from Biogen. The institution of Dr. Finkel has received research support from Capricor. The institution of Dr. Finkel has received research support from Catabasis. The institution of Dr. Finkel has received research support from ReveraGen. The institution of Dr. Finkel has received research support from Roche. The institution of Dr. Finkel has received research support from Scholar Rock. Dr. Finkel has received intellectual property interests from a discovery or technology relating to health care. An immediate family member of Dr. Finkel has received intellectual property interests from a discovery or technology relating to health care. Dr. Finkel has received personal compensation in the range of $0-$499 for serving as a Speaker in workshop with National Academy of Sciences. Dr. Finkel has a non-compensated relationship as a advisor with n-Lorem Foundation that is relevant to AAN interests or activities. Dr. Finkel has a non-compensated relationship as a Board Member with EveryLife Foundation that is relevant to AAN interests or activities.
Alan K. Percy, MD, FAAN	Dr. Percy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia Pharmaceuticals. Dr. Percy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Taysha Gene Therapies. Dr. Percy has received personal compensation in the range of $0-$499 for serving as a Consultant for Neurogene. Dr. Percy has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Taysha Gene Therapies. Dr. Percy has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for IOS Press.
Efrain D. Salgado, MD	Dr. Salgado has nothing to disclose.
David S. Zee, MD	Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for florida legal. Dr. Zee has received publishing royalties from a publication relating to health care. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a lectuer with u of pittsburg physical therapy. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a lecturer with johms hopkins CME.
Peter A. Calabresi, MD, FAAN	Dr. Calabresi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Dr. Calabresi has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Calabresi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Idorsia. An immediate family member of Dr. Calabresi has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for MyMD. Dr. Calabresi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Myelin Repair Foundation. The institution of Dr. Calabresi has received research support from Genentech. Dr. Calabresi has received publishing royalties from a publication relating to health care. Dr. Calabresi has received personal compensation in the range of $500-$4,999 for serving as a Study Section Member with NIH. Dr. Calabresi has received personal compensation in the range of $500-$4,999 for serving as a Grant reveiwer with Myelin Repair Foundation. Dr. Calabresi has received personal compensation in the range of $500-$4,999 for serving as a Speaker for CME with NYAS. Dr. Calabresi has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Academic CME.
Enrico S. Bertini, MD	Dr. Bertini has received personal compensation for serving as an employee of Bambino Gesu' Children's Resesarch Hospital.
Elizabeth M. Berry-Kravis, MD, PhD	The institution of Dr. Berry-Kravis has received research support from NIH. The institution of Dr. Berry-Kravis has received research support from Ionis. The institution of Dr. Berry-Kravis has received research support from Zynerba. The institution of Dr. Berry-Kravis has received research support from Roche. The institution of Dr. Berry-Kravis has received research support from CDC. The institution of Dr. Berry-Kravis has received research support from FRAXA Research Foundation. The institution of Dr. Berry-Kravis has received research support from GeneTx. The institution of Dr. Berry-Kravis has received research support from Angelman Syndrome Foundation. The institution of Dr. Berry-Kravis has received research support from Acadia. The institution of Dr. Berry-Kravis has received research support from Ultragenyx. The institution of Dr. Berry-Kravis has received research support from Mallinckrodt. The institution of Dr. Berry-Kravis has received research support from Together Strong Foundation. The institution of Dr. Berry-Kravis has received research support from Zevra. The institution of Dr. Berry-Kravis has received research support from Taysha. The institution of Dr. Berry-Kravis has received research support from Tetra. The institution of Dr. Berry-Kravis has received research support from Neuren.
David N. Lieberman, MD, PhD	Dr. Lieberman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia Pharmaceuticals. Dr. Lieberman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Taysha Gene Therapies. Dr. Lieberman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurogene.
Alexandra Araujo, MD, PhD	Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ROCHE. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ROCHE. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pfizer. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for PTC Therapeutics. Dr. Araujo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Araujo has received research support from Roche. Dr. Araujo has received research support from PTC Therapeutics.
Paulo P. Fontoura, MD, PhD, FAAN	Dr. Fontoura has received personal compensation for serving as an employee of F. Hoffmann La Roche. Dr. Fontoura has stock in Roche Pharmaceuticals.
Timothy A. Benke, MD, PhD	The institution of Dr. Benke has received research support from NIH, RSRT, IRSF and Children's Hospital Colorado. The institution of Dr. Benke has received research support from Acadia, GW, RSRT, Ovid/Takeda, Marinus. The institution of Dr. Benke has received research support from Acadia, CUREGRI, GRINtherapeutics, GW, IRSF, Marinus, Neurogene, Taysha, Ultragenyx and Zogenix/UCB; .
Robyn A. Filipink, MD	The institution of an immediate family member of Dr. Filipink has received research support from NIH . Dr. Filipink has received personal compensation in the range of $0-$499 for serving as a Author with Medlink.
Mohammad A. Al-Muhaizea, MD	Dr. Al-Muhaizea has nothing to disclose.
Eric D. Marsh, MD, PhD	Dr. Marsh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia Pharmacuticals. Dr. Marsh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Stoke Therapeutics. Dr. Marsh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acadia Pharmaceuticals. The institution of Dr. Marsh has received research support from NIH. The institution of Dr. Marsh has received research support from Rett Syndrome Research Trust. The institution of Dr. Marsh has received research support from International Rett Syndrome Foundation. The institution of Dr. Marsh has received research support from Eagles Autism Challenge. The institution of Dr. Marsh has received research support from LouLou Foundation. The institution of Dr. Marsh has received research support from International CDKL5 Resarch Foundation. The institution of Dr. Marsh has received research support from Acadia Pharmaceuticals. The institution of Dr. Marsh has received research support from Marinus. The institution of Dr. Marsh has received research support from Stoke Therapeutics. The institution of Dr. Marsh has received research support from Takeda Pharmaceuticals. Dr. Marsh has received personal compensation in the range of $500-$4,999 for serving as a Grant Review with NIH. Dr. Marsh has received personal compensation in the range of $5,000-$9,999 for serving as a Expert Witness with Department of Human Services. Dr. Marsh has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Medscape.
Colleen M. Buhrfiend, MD	Dr. Buhrfiend has nothing to disclose.
Alexander Paciorkowski, MD	The institution of Dr. Paciorkowski has received research support from University of Rochester.
Mona Darwish, PhD	Dr. Darwish has received personal compensation for serving as an employee of Acadia.
May Han, MD	Dr. Han has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Han has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arena Pharmaceuticals.
Teresa Frohman, PA	No disclosure on file
Michael S. Rafii, MD, PhD	Dr. Rafii has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AC Immune. Dr. Rafii has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Keystone Bio. Dr. Rafii has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alzheon.
Mario A. Saporta, MD, PhD, FAAN	Dr. Saporta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for SwanBio. Dr. Saporta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Pharnext. Dr. Saporta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Applied Therapeutics.
Stephan Zuchner, MD, FAAN	Dr. Zuchner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Applied Therapeutics. The institution of Dr. Zuchner has received research support from Muscular Dystrophy Association. The institution of Dr. Zuchner has received research support from CMT Association. Dr. Zuchner has received intellectual property interests from a discovery or technology relating to health care.
Jessica Carpenter, MD	Dr. Carpenter has nothing to disclose.
Ksenija Gorni	Dr. Gorni has received personal compensation for serving as an employee of Hoffman La Roche.
Seyed A. Fatemi, MD, MBA	Dr. Fatemi has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for RCO law. The institution of Dr. Fatemi has received research support from Minoryx. The institution of Dr. Fatemi has received research support from Viking Therapeutics. The institution of Dr. Fatemi has received research support from Swanbio Therapeutics . The institution of Dr. Fatemi has received research support from Autobahn Therapeutics. The institution of Dr. Fatemi has received research support from Nuvelution. The institution of Dr. Fatemi has received research support from NIH. The institution of Dr. Fatemi has received research support from A Cure for Ellie Foundation. The institution of Dr. Fatemi has received research support from Brian's Hope Foundation . Dr. Fatemi has received intellectual property interests from a discovery or technology relating to health care. Dr. Fatemi has a non-compensated relationship as a Director (Board member) with ALDConnect that is relevant to AAN interests or activities.
Robin Ryther, MD, PhD	The institution of Dr. Ryther has received research support from Acadia.
Laurent Servais	Laurent Servais has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Laurent Servais has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. Laurent Servais has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Astellas. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sarepta. The institution of Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Evox. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PTC. Laurent Servais has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sysnav. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BioHaven. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Dyne. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zentech. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MitoRx. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lupin. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Fibrogen. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alltrana. Laurent Servais has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Illumina. Laurent Servais has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. The institution of Laurent Servais has received research support from Roche. The institution of Laurent Servais has received research support from Novartis. The institution of Laurent Servais has received research support from Biogen. The institution of Laurent Servais has received research support from Zentech. The institution of Laurent Servais has received research support from BioHaven. The institution of Laurent Servais has received research support from PerkinHalmers. The institution of Laurent Servais has received research support from Scholar Rock.
Timothy J. Feyma, MD	Dr. Feyma has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PTC Therapeutics. Dr. Feyma has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for PTC Therapeutics.
Dilesh Doshi, PharmD	Dr. Doshi has received personal compensation for serving as an employee of Acadia Pharmaceuticals.
Amy Conger	No disclosure on file
Keith Van Haren, MD	Dr. Van Haren has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Viking Therapeutics. Dr. Van Haren has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bluebirdbio. Dr. Van Haren has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Orpheris. Dr. Van Haren has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Autobahn. Dr. Van Haren has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for PRIME, Inc. The institution of Dr. Van Haren has received research support from Minoryx. The institution of Dr. Van Haren has received research support from bluebirdbio. Dr. Van Haren has a non-compensated relationship as a Board of Directors with ALD Connect that is relevant to AAN interests or activities. Dr. Van Haren has a non-compensated relationship as a Scientific Advisory Board with United Leukodystrophy Foundation that is relevant to AAN interests or activities.
Ariel M. Lyons-Warren, MD, PhD	Dr. Lyons-Warren has received personal compensation in the range of $0-$499 for serving as a Consultant for Guidepoint. Dr. Lyons-Warren has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology. The institution of Dr. Lyons-Warren has received research support from NIH.
David Bearden, MD	Dr. Bearden has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Bearden has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Praxis. Dr. Bearden has received personal compensation in the range of $100,000-$499,999 for serving as an Expert Witness for law firms.
James M. Youakim, MD	Dr. Youakim has received personal compensation for serving as an employee of Acadia Pharmaceuticals. Dr. Youakim has stock in Acadia Pharmaceuticals.
John A. Morren, MD, FAAN	Dr. Morren has received publishing royalties from a publication relating to health care.
Christoph J. Schankin, MD	The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lilly. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Teva. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lundbeck. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Teva. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Grünenthal. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Lilly. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. The institution of Dr. Schankin has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Teva. The institution of Dr. Schankin has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Lundbeck. Dr. Schankin has stock in Zynnon.
Jonathan Santoro, MD	Dr. Santoro has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB. Dr. Santoro has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Cycle Pharma.
Raghav Govindarajan, MD, FAAN	Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for MT pharma. Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx. Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Catalyst. Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche . Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta. Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amicus. Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Dr. Govindarajan has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Alexion. Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for MT pharma . Dr. Govindarajan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Catalyst. Dr. Govindarajan has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Argenx. Dr. Govindarajan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biohaven. Dr. Govindarajan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for UCB. Dr. Govindarajan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Takeda. Dr. Govindarajan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Abbvie. The institution of Dr. Govindarajan has received research support from Band of Hope . The institution of Dr. Govindarajan has received research support from Alexion. Dr. Govindarajan has received publishing royalties from a publication relating to health care.
Arnold J. Sansevere, MD	Dr. Sansevere has nothing to disclose.
Amitha Ananth, MD	Dr. Ananth has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Reata Therapeutics. The institution of Dr. Ananth has received research support from Acadia Pharmaceuticals.
Kathie M. Bishop, PhD	Dr. Bishop has received personal compensation for serving as an employee of Acadia Pharmaceuticals, Inc. . Dr. Bishop has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for DTx Pharma. Dr. Bishop has stock in Acadia Pharmaceuticals, Inc..
Dana B. Harrar, MD	The institution of Dr. Harrar has received research support from NIH. Dr. Harrar has received publishing royalties from a publication relating to health care.
Ahmed Negida, MD, PhD	Dr. Negida has nothing to disclose.
Daniel Glaze, MD	Dr. Glaze has nothing to disclose.
Heidemarie Kletzl	Heidemarie Kletzl has received personal compensation for serving as an employee of Hoffmann-La Roche.
Jeffrey Neul, MD, PhD	Dr. Neul has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia. Dr. Neul has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GW Pharmaceuticals. Dr. Neul has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Signant Health. Dr. Neul has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Analysis Group. Dr. Neul has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Taysha Gene Therapies. Dr. Neul has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alcyone. Dr. Neul has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ovid. Dr. Neul has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Neul has stock in LizardBio. The institution of Dr. Neul has received research support from NIH. The institution of Dr. Neul has received research support from Acadia. The institution of Dr. Neul has received research support from GW Pharmaceuticals. The institution of Dr. Neul has received research support from International Rett Syndrome Foundation. The institution of Dr. Neul has received research support from Rett Syndrome Research Trust.
Sarah Schlatterer, MD, PhD	The institution of Dr. Schlatterer has received research support from Van Metre Foundation.
Carolyn Dickinson, NP	Ms. Dickinson has nothing to disclose.
Ryan Carrier, MD	Dr. Carrier has received personal compensation in the range of $500-$4,999 for serving as a Project Stakeholder with TANGO2 Research Foundation .
Michelle A. Farrar	Michelle A. Farrar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Michelle A. Farrar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Michelle A. Farrar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Michelle A. Farrar has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Michelle A. Farrar has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche.
David E. Horvat, MD	Dr. Horvat has nothing to disclose.
Ryan Kammeyer, MD	Dr. Kammeyer has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Ogborn-Mihm Trial Lawyers. The institution of Dr. Kammeyer has received research support from Rocky Mountain Multiple Sclerosis Center.
Mellad Khoshnood, MD	Dr. Khoshnood has nothing to disclose.
Saba Jafarpour, MD	Dr. Jafarpour has nothing to disclose.
Edmar Zanoteli	Edmar Zanoteli has nothing to disclose.
Eleni Gaki, MD	Dr. Gaki has received personal compensation for serving as an employee of Roche. Dr. Gaki has received stock or an ownership interest from Roche Products Ltd.
Elarbi Goufa	Mr. Goufa has nothing to disclose.
Manouchehr Amanat	Mr. Amanat has nothing to disclose.
Kristen Sportiello	The institution of an immediate family member of Ms. Sportiello has received research support from National Institutes of Health (NIH). An immediate family member of Ms. Sportiello has received personal compensation in the range of $50,000-$99,999 for serving as a Research Assistant with National Institutes of Health (NIH).
Elizabeth H. Jacobs	An immediate family member of Ms. Jacobs has received personal compensation for serving as an employee of Frida. The institution of Ms. Jacobs has received research support from National Institutes of Health.
Amena S. Fine, MD, PhD	The institution of Dr. Fine has received research support from NIH.
Sydney Peters	Ms. Peters has nothing to disclose.
Sam Javadian	Mr. Javadian has nothing to disclose.
Esha Kaushal, PhD	Dr. Kaushal has nothing to disclose.
Michael Rabbia	No disclosure on file
Leslie Nelson	No disclosure on file
Adriana Rebelo	No disclosure on file
Amy Barrett	No disclosure on file
Birgit Jaber	No disclosure on file
Dmitry Vlodavets	No disclosure on file
David Summers	No disclosure on file
Matt Danzi	Matt Danzi has nothing to disclose.
Laura Palfreeman	No disclosure on file
Melanie Manning	Melanie Manning has nothing to disclose.
Lina Patel	No disclosure on file
Gordon Worley	No disclosure on file
Natalie Boyd	Natalie Boyd has nothing to disclose.
Di Di An	No disclosure on file
Catherine Franklin	Catherine Franklin has nothing to disclose.
Rashad G. Mohamed, MBBS	Dr. Mohamed has nothing to disclose.
Amr Elrosasy	Amr Elrosasy has nothing to disclose.
Benjamin Vogel	Benjamin Vogel has nothing to disclose.
Stephanie Santoro	No disclosure on file
Benita Tamrazi	No disclosure on file
Lina Nguyen	Lina Nguyen has nothing to disclose.
Joaquin Espinosa	Joaquin Espinosa has received personal compensation in the range of $0-$499 for serving as a Consultant for Biohaven.
Christina Nemeth Mertz	No disclosure on file
Mohamed Abo Zeid	No disclosure on file
Ines Garofolo	No disclosure on file
Nourhan Hassan	No disclosure on file
Ezzat Hashemi	No disclosure on file
Yu-Ting Liu	No disclosure on file
Julia Keenan	Julia Keenan has nothing to disclose.
Ashlie Nguyen	Ashlie Nguyen has nothing to disclose.
Caroline Conley	No disclosure on file
Katelyn Staso	No disclosure on file
Shruthi Voleti	No disclosure on file
Shreya Mandalapu	Shreya Mandalapu has nothing to disclose.
Alina Ghazou	No disclosure on file
Oyebimpe Olayinka-Amao	No disclosure on file
Susan Martin	No disclosure on file

��ɫ��

��ɫ��