2026 Annual Meeting | N2 - Neuroscience in the Clinic: Neurological Care of Individuals with Down Syndrome Across the Lifespan

Date Sunday 04/19/26

Time 03:30 PM - 05:30 PM CDT Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Neuroscience in the Clinic Session

Director(s) Chad Hales, MD, PhD, FAAN, Jonathan Santoro, MD

Topic(s) Child Neurology and Developmental Neurology, General Neurology, Cerebrovascular Disease and Interventional Neurology, Autoimmune Neurology

Learning Objectives Participants should be able to identify the unique aspsects of epilepsy care in individuals with Down syndrome ranging from differences in age of onset, response to anti-seizure medications, and long-term sequelae; understand the core clinical symptoms of Down Syndrome Regression Disorder (DSRD) and formulate therapeutic management plans based on neurodiagnostic study results; and understand the unique causes of Alzheimer's in persons with Down syndrome and understand novel therapeutic strategies.

CME Available 2.00 CME credits

Core Competencies Patient Care & Procedural Skills, Interpersonal and Communication Skills, Medical Knowledge, Practice-based Learning and Improvement, Systems-based Practice

Program Level Intermediate

Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Non-neurologist, Advanced Practice Provider, Medical Student

Teaching Styles Case-based, Didactic, Audience Participation

Event Timeline
03:30 PM - 03:33 PM CDT	Introduction	Introduction Chad Hales, MD, PhD, FAAN, Jonathan Santoro, MD
03:33 PM - 04:03 PM CDT	Speaker	Epilepsy in Down Syndrome Across the Lifespan Carl E. Stafstrom, MD, PhD
04:03 PM - 04:15 PM CDT	Speaker	Abstract Presentation #1
04:15 PM - 04:45 PM CDT	Speaker	Down Syndrome Regression Disorder and Abstract Presentation #2 Jonathan Santoro, MD
04:45 PM - 04:57 PM CDT	Speaker	Abstract Presentation #3
04:57 PM - 05:27 PM CDT	Speaker	Alzheimer's in Down Syndrome Beau M. Ances, MD, PhD, MS, FAAN
05:27 PM - 05:30 PM CDT	Closing Remarks	Conclusion Chad Hales, MD, PhD, FAAN, Jonathan Santoro, MD

Faculty Disclosures
Chad Hales, MD, PhD, FAAN	The institution of Dr. Hales has received research support from BrightFocus foundation. The institution of Dr. Hales has received research support from NIH. The institution of Dr. Hales has received research support from State of Georgia. Dr. Hales has a non-compensated relationship as a committee member with AAN that is relevant to AAN interests or activities.
Jonathan Santoro, MD	Dr. Santoro has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB. Dr. Santoro has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Cycle Pharma. Dr. Santoro has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Dianthus. Dr. Santoro has received personal compensation in the range of $500-$4,999 for serving as a Consultant for National Down Syndrome Society.
Carl E. Stafstrom, MD, PhD	Dr. Stafstrom has nothing to disclose.
Beau M. Ances, MD, PhD, MS, FAAN	Dr. Ances has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NIH.
Angela Rachubinski, PhD	The institution of Dr. Rachubinski has received research support from NIH.
GenaLynne Mooneyham, MD	Dr. Mooneyham has received research support from National Institutes of Health.
Ryan Kammeyer, MD	The institution of Dr. Kammeyer has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amgen. The institution of Dr. Kammeyer has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Kammeyer has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Ogborn-Mihm Trial Lawyers. The institution of Dr. Kammeyer has received research support from Rocky Mountain Multiple Sclerosis Center.
Daniela Ospina Cardona, Neurobiologist	Mrs. Ospina Cardona has nothing to disclose.
Kevin V. Lemley, MD, PhD	Prof. Lemley has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for International Pediatric Nephrology Association. Prof. Lemley has received personal compensation in the range of $0-$499 for serving as a Webinar participant with National Institutes of Health/NIDDK.
Benjamin Vogel	Benjamin Vogel has nothing to disclose.
Elizabeth Mayne, MD	Dr. Mayne has received research support from NINDS-CNCDP K12.
Maeve C. Lucas, BS	Ms. Lucas has nothing to disclose.
Brian Skotko, MD, MPP	Dr. Skotko has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Gerson Lehrman Group. Dr. Skotko has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Massachusetts Down Syndrome Congress. Dr. Skotko has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for National Center for Prenatal and Postnatal Down Syndrome Resources. Dr. Skotko has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Legal groups. An immediate family member of Dr. Skotko has stock in Yext. An immediate family member of Dr. Skotko has stock in Snowflake. The institution of Dr. Skotko has received research support from NIH. The institution of Dr. Skotko has received research support from PCORI. The institution of Dr. Skotko has received research support from LuMind IDSC Down Syndrome Foundation. Dr. Skotko has received publishing royalties from a publication relating to health care.
Nidhiben A. Anadani, MD	Dr. Anadani has nothing to disclose.
Hannah Mager	Ms. Mager has received research support from National Institute of Mental Health. Ms. Mager has received personal compensation in the range of $50,000-$99,999 for serving as a graduate student with National Institute of Mental Health.
Sarah Lee, MD	Dr. Lee has nothing to disclose.
Joaquin Espinosa	Joaquin Espinosa has received personal compensation in the range of $0-$499 for serving as a Consultant for Biohaven.
Mariam M. Yousuf, BS	Miss Yousuf has nothing to disclose.
Bryan T. Lei, MS	Mr. Lei has nothing to disclose.
Lina Nguyen	Lina Nguyen has nothing to disclose.
Eileen Quinn, MD	Dr. Quinn has nothing to disclose.
Mackenzie Silverman, MD	Mr. Silverman has nothing to disclose.
Lilia Kazerooni, BS	Miss Kazerooni has nothing to disclose.
Tena Rosser, MD	Dr. Rosser has received publishing royalties from a publication relating to health care. Dr. Rosser has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant with Children's Tumor Foundation. Dr. Rosser has received personal compensation in the range of $500-$4,999 for serving as a Speaker/consultant with Springworks Therapeutics.
Melanie Manning	Melanie Manning has nothing to disclose.
Pavel Khil, PhD	Dr. Khil has received personal compensation for serving as an employee of Axle Informatics.
Deepti Nagesh, MBBS	Dr. Nagesh has nothing to disclose.
Catherine Franklin	Catherine Franklin has nothing to disclose.
Michael S. Rafii, MD, PhD	Dr. Rafii has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AC Immune. Dr. Rafii has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Keystone Bio. Dr. Rafii has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alzheon.
PRITI R. PANDIT, PhD	Dr. PANDIT has nothing to disclose.
Samuel T. Otey, BS	Mr. Otey has nothing to disclose.
Pat R. Levitt, MD	Dr. Levitt has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for Independent Citizens Oversite Committee - California Institute for Regenerative Medicine. Dr. Levitt has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for Lieber Institute for Brain Development. The institution of Dr. Levitt has received research support from NIH. The institution of Dr. Levitt has received research support from NSF.
Christopher M. Bartley, MD, PhD	Dr. Bartley has stock in NowRx, Inc.. The institution of Dr. Bartley has received research support from Deeda Blair Research Initiative for Disorders of the Brain (FNIH). The institution of Dr. Bartley has received research support from Howard Hughes Medical Institute. Dr. Bartley has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Commonwealth Club.
Noemi Spinazzi, MD	Dr. Spinazzi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ionis Pharmaceuticals. Dr. Spinazzi has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Saldivar & Associates. The institution of Dr. Spinazzi has received research support from NIH.

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