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2026 Annual Meeting | N4 - Neuroscience in the Clinic: Waves of Change in Neurology: Rethinking Cortical Spreading Depolarization (CSD)

Tuesday 04/21/26
01:00 PM - 03:00 PM CDT Add To Calendar
This program will be presented both in-person and online
This program will be available in the meeting's On Demand product.
Neuroscience in the Clinic Session
Rashmi B. Halker Singh, MD, FAAN, Sarah E. Nelson, MD, MPH, FAAN
General Neurology, Headache, Neuro Trauma and Critical Care
Cortical spreading depolarization (CSD) is gaining momentum as a key mechanism in neuroscience, with growing relevance across a range of neurological conditions—including migraine, subarachnoid hemorrhage, and beyond. This session brings together leading scientists and clinicians to explore the pathophysiology of CSD and its emerging clinical implications. Attendees should gain insights into how CSD may influence patient care across diverse neurological populations, and what it could mean for future management strategies.
2.00 CME credits
Medical Knowledge, Practice-based Learning and Improvement, Quality Improvement
Intermediate
Fellow, Resident, General Neurologist, Specialist Neurologist, Advanced Practice Provider, Neurohospitalist, Medical Student
Case-based, Didactic
Event Timeline
01:00 PM - 01:05 PM CDT Introduction Introduction
Rashmi B. Halker Singh, MD, FAAN
01:05 PM - 01:20 PM CDT Speaker Clinical Case
Sarah E. Nelson, MD, MPH, FAAN
01:20 PM - 01:45 PM CDT Speaker Spreading Depolarization: Brain Death versus Reboot
Jens P. Dreier, MD
01:45 PM - 01:55 PM CDT Speaker Abstract Presentation #1
01:55 PM - 02:20 PM CDT Speaker The Role of Cortical Spreading Depolarization in Stroke and Seizures
David Y. Chung, MD
02:20 PM - 02:30 PM CDT Speaker Abstract Presentation #2
02:30 PM - 03:00 PM CDT Q&A Panel Discussion
Rashmi B. Halker Singh, MD, FAAN, Sarah E. Nelson, MD, MPH, FAAN, Jens P. Dreier, MD, David Y. Chung, MD
Faculty Disclosures
Rashmi B. Halker Singh, MD, FAAN Dr. Halker Singh has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pfizer. Dr. Halker Singh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Dr. Halker Singh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lundbeck. Dr. Halker Singh has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Current Neurology & Neuroscience Reports. Dr. Halker Singh has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Headache Journal. Dr. Halker Singh has received publishing royalties from a publication relating to health care. Dr. Halker Singh has received personal compensation in the range of $5,000-$9,999 for serving as a CME speaker with Pri-med. Dr. Halker Singh has received personal compensation in the range of $500-$4,999 for serving as a CME speaker with Medscape.
Sarah E. Nelson, MD, MPH, FAAN Dr. Nelson has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology Journal. Dr. Nelson has received publishing royalties from a publication relating to health care. Dr. Nelson has a non-compensated relationship as a Women Leading in Neurology Program with 好色先生 that is relevant to AAN interests or activities.
Jens P. Dreier, MD Prof. Dreier has nothing to disclose.
David Y. Chung, MD The institution of Dr. Chung has received research support from NIH/NINDS. The institution of Dr. Chung has received research support from Brain Aneurysm Foundation. The institution of Dr. Chung has received research support from Angea Biotherapeutics.
Keiko Ihara, MD The institution of Dr. Ihara has received research support from American Heart Association.
Britta Lindquist, MD, PhD The institution of Dr. Lindquist has received research support from National Institutes of Health NINDS.
Chisato Iba Ms. Iba has nothing to disclose.
Anthony DiGiorgio No disclosure on file
Tsubasa Takizawa, MD, PhD Prof. Takizawa has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer. Prof. Takizawa has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Otsuka. Prof. Takizawa has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. Prof. Takizawa has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Teijin. Prof. Takizawa has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Prof. Takizawa has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Daiichi Sankyo. Prof. Takizawa has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Otsuka. Prof. Takizawa has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Eli Lilly. Prof. Takizawa has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Daiichi Sankyo. Prof. Takizawa has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Amgen. Prof. Takizawa has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sawai. Prof. Takizawa has received research support from Eli Lilly. Prof. Takizawa has received research support from JSPS KAKENHI. Prof. Takizawa has received research support from Pfizer.
Yoshikane Izawa, MD, PhD The institution of Dr. Izawa has received research support from Ministry of 好色先生, Culture, Sports, Science and Technology (JAPAN).
Laura B. Ngwenya, MD, PhD Dr. Ngwenya has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sophysa, USA. The institution of Dr. Ngwenya has received research support from NINDS/NIH. The institution of Dr. Ngwenya has received research support from Abbott.
Edilberto Amorim, MD The institution of Dr. Amorim has received research support from American Heart Association. The institution of Dr. Amorim has received research support from Society of Critical Care Medicine. The institution of Dr. Amorim has received research support from Zoll Foundation. The institution of Dr. Amorim has received research support from Hellman Foundation. The institution of Dr. Amorim has received research support from Regents of the University of California. The institution of Dr. Amorim has received research support from Citizens United Against Epilepsy. The institution of Dr. Amorim has received research support from Regents of the University of California. The institution of Dr. Amorim has received research support from American Heart Association. The institution of Dr. Amorim has received research support from NIH. The institution of Dr. Amorim has received research support from Department of Defense. The institution of Dr. Amorim has received research support from Department of Defense. The institution of Dr. Amorim has received research support from American Heart Association.
Jed Hartings, PhD Dr. Hartings has nothing to disclose.
Jennifer Goldthwait, RN Ms. Goldthwait has nothing to disclose.
Brandon P. Foreman, MD Dr. Foreman has received personal compensation in the range of $0-$499 for serving as a Consultant for UCB Pharma Inc. Dr. Foreman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ceribell, Inc. Dr. Foreman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sage Therapeutics. Dr. Foreman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Marinus Pharmaceuticals. Dr. Foreman has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for UCB Pharma Inc.. The institution of Dr. Foreman has received research support from DOD/AMRMC. The institution of Dr. Foreman has received research support from Biogen, Inc.. The institution of Dr. Foreman has received research support from DOD/AFRL. The institution of Dr. Foreman has received research support from NSF SCH:INT. The institution of Dr. Foreman has received research support from NIH/NIBIB. The institution of Dr. Foreman has received research support from DOD/JWMRP. The institution of Dr. Foreman has received research support from Marinus Pharmaceuticals. Dr. Foreman has received personal compensation in the range of $500-$4,999 for serving as a Honoraria with Natus Medical Incorporated. Dr. Foreman has received personal compensation in the range of $500-$4,999 for serving as a Honoraria with Ceribell, Inc.. Dr. Foreman has received personal compensation in the range of $0-$499 for serving as a Peer-to-peer program honoraria with Marinus Pharmaceuticals.
Jin Nakahara, MD, PhD, FAAN Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Mitsubishi-Tanabe. Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Chugai. Prof. Nakahara has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Novartis. Prof. Nakahara has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Prof. Nakahara has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Alexion. Prof. Nakahara has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Chugai. Prof. Nakahara has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Mitsubishi-Tanabe. Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Takeda. Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB. Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amgen. Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai. Prof. Nakahara has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for The Japanese Society for Internal Medicine. The institution of Prof. Nakahara has received research support from Chugai. The institution of Prof. Nakahara has received research support from Japan Society for the Promotion of Science.
Danielle Sandsmark, MD The institution of Dr. Sandsmark has received research support from NINDS. The institution of Dr. Sandsmark has received research support from BrainBox Solutions Inc. The institution of Dr. Sandsmark has received research support from Department of Defense.
Miyuki Unekawa, PhD Ms. Unekawa has nothing to disclose.