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2026 Annual Meeting | N5 - Neuroscience in the Clinic: Circadian Neuroscience: Biological Timing Matters in Neurology

Wednesday 04/22/26
01:00 PM - 03:00 PM CDT Add To Calendar
McCormick Place West | W183b
This program will be presented both in-person and online
This program will be available in the meeting's On Demand product.
Neuroscience in the Clinic Session
Roneil Malkani, MD, FAAN, Phyllis C. Zee, MD, PhD
General Neurology, Cerebrovascular Disease and Interventional Neurology, Neuro-oncology
Participants should be able to describe the role of circadian rhythms in neurology and circadian dysfunction as risk factor for neurological diseases, be able to describe mechanisms linking circadian dysfunction in neurological diseases, and be able to identify strategies to address circadian dysfunction in headache disorders and neurodegenerative disease.
2.00 CME credits
Patient Care & Procedural Skills, Medical Knowledge, Practice-based Learning and Improvement
Intermediate
Fellow, Resident, General Neurologist, Specialist Neurologist, Non-neurologist, Advanced Practice Provider, Medical Student
Case-based, Didactic

Program Materials

Event Timeline
01:00 PM - 01:05 PM CDT Introduction Introduction
Roneil Malkani, MD, FAAN
01:05 PM - 01:10 PM CDT Speaker Case Presentation
KuangHua Guo, MD, PhD
01:10 PM - 01:35 PM CDT Speaker Clocks, Sleep, and Risk of Neurological Disease
Amita Sehgal, PhD
01:35 PM - 02:00 PM CDT Speaker Circadian Rhythm Disruption in Neurodegeneration: Mechanisms, Evaluation, and Circadian-based Therapeutic Approaches
Aleksandar Videnovic, MD, MSc, FAAN
02:00 PM - 02:25 PM CDT Speaker Circadian Rhythm Disruption in Headache: Mechanisms, Evaluation, and Circadian-based Therapeutic Approaches
Rachel Darken, MD, PhD, FAAN
02:25 PM - 02:35 PM CDT Abstract 001 - Utilizing the Circadian Clock to Enhance Temozolomide Efficacy in Pediatric Gliomas
Ella A. Nettnin
02:35 PM - 02:45 PM CDT Abstract 002 - Circadian Regulation of the Endogenous Brain Clearance System Promotes Hematoma Resolution after Intracerebral Hemorrhage in Mice
Hailu Chen, PhD
02:45 PM - 03:00 PM CDT Q&A Case Follow-up and Q&A
Roneil Malkani, MD, FAAN, Phyllis C. Zee, MD, PhD, Rachel Darken, MD, PhD, FAAN, Aleksandar Videnovic, MD, MSc, FAAN, Amita Sehgal, PhD, KuangHua Guo, MD, PhD
Faculty Disclosures
Roneil Malkani, MD, FAAN Dr. Malkani has received personal compensation in the range of $500-$4,999 for serving as a Author with 好色先生. Dr. Malkani has received personal compensation in the range of $500-$4,999 for serving as a Reviewer with Weston Family Foundation. Dr. Malkani has received personal compensation in the range of $500-$4,999 for serving as a Consultant with American Academy of Sleep Medicine. Dr. Malkani has received personal compensation in the range of $500-$4,999 for serving as a Honoraria with AANI. Dr. Malkani has a non-compensated relationship as a Board Member with Illinois Sleep Society that is relevant to AAN interests or activities. Dr. Malkani has a non-compensated relationship as a Review editor on editorial board with Frontiers that is relevant to AAN interests or activities.
Phyllis C. Zee, MD, PhD Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai. Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Takeda. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz. Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Apnimed. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CVS Caremark. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Harmony. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Harmony Biosciences. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz Pharmaceuticals Inc.. Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Apnimed. Dr. Zee has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for World Sleep Society. Dr. Zee has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for American Brain Foundation. An immediate family member of Dr. Zee has stock in Teva. An immediate family member of Dr. Zee has stock in Pfizer. The institution of Dr. Zee has received research support from National Institutes of Health. Dr. Zee has received intellectual property interests from a discovery or technology relating to health care. Dr. Zee has received intellectual property interests from a discovery or technology relating to health care. Dr. Zee has received publishing royalties from a publication relating to health care.
Rachel Darken, MD, PhD, FAAN Dr. Darken has received personal compensation in the range of $0-$499 for serving as a Consultant for Lundbeck. The institution of Dr. Darken has received research support from PCORI.
Aleksandar Videnovic, MD, MSc, FAAN Dr. Videnovic has nothing to disclose.
Amita Sehgal, PhD The institution of Dr. Sehgal has received research support from Howard Hughes Medical Institute. Dr. Sehgal has received personal compensation in the range of $10,000-$49,999 for serving as a Advisor with Leon Levy Foundation.
Ella A. Nettnin Ms. Nettnin has nothing to disclose.
Maria Isabel Barros Guinle, MS Ms. Barros Guinle has nothing to disclose.
Christy Wilson, PhD Dr. Wilson has nothing to disclose.
Enrique E. Garcia, MD Dr. Garcia has received personal compensation for serving as an employee of Takeda Pharmaceuticals.
Laura M. Prolo, MD, PhD Dr. Prolo has nothing to disclose.
Rui Wang, MD Dr. Wang has nothing to disclose.
Fudhial F. Sayed Mr. Sayed has nothing to disclose.
Hailu Chen, PhD Dr. Chen has nothing to disclose.
KuangHua Guo, MD, PhD Dr. Guo has nothing to disclose.