Abstract Details

Title Trends in the Incidence and Prevalence of Multiple Sclerosis in Pakistan from 1990 to 2021: A Secondary Analysis of the Global Burden of Disease Study

Topic Multiple Sclerosis

Presentation(s) P9 - Poster Session 9 (11:45 AM-12:45 PM)

Poster/Presentation
Number 1-001

Objective We aim to identify the trends in the incidence and prevalence of multiple sclerosis (MS) in Pakistan from 1990 to 2021, stratified by sex and provinces of Pakistan.

Background Multiple sclerosis (MS) is associated with high morbidity and mortality, but contemporary data regarding its distribution in Pakistan is not available.

Design/Methods We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to obtain age-standardized rates for incidence (ASIR) and prevalence (ASPR) of MS per 100,000 people in Pakistan, with the 95% uncertainty intervals (UIs). Joinpoint regression was used to calculate the annual percentage change (APC) and average APC (AAPC) in rates.

Results The ASIR of MS in Pakistan increased from 0.45 (0.37 to 0.54) per 100,000 in 1990 to 0.50 (0.42 to 0.59) per 100,000 in 2021 (AAPC: 0.38). Females showed higher ASIR than males both in 1990 (0.53 versus 0.37) and 2021 (0.60 versus 0.41) as well as a greater AAPC (0.36 versus 0.35). The highest AAPC in ASIR per 100,000 was observed in Islamabad Capital Territory (0.63) and the lowest in Gilgit Baltistan (0.29). The ASPR of MS in Pakistan increased from 8.34 (6.67 to 10.17) per 100,000 in 1990 to 9.80 (8.12 to 11.62) per 100,000 in 2021 (AAPC: 0.52). Females also showed a greater ASPR than males both in 1990 (10.56 versus 6.37) and 2021 (12.31 versus 7.38), with a greater AAPC (0.50 versus 0.48). The highest AAPC in ASPR per 100,000 was observed in Islamabad Capital Territory (0.84) and the lowest in Khyber Pakhtunkhwa (0.38).

Conclusions Our results indicate increasing incidence and prevalence of MS in Pakistan across both sexes and in all provinces, with the highest burden among females. Public awareness is an absolute necessity to control the rising trends of MS in a lower-middle income country like Pakistan.

Authors/Disclosures
Madelyn N. Ross PRESENTER	Ms. Ross has nothing to disclose.
Syed H. Inam, MD	Dr. Inam has nothing to disclose.
Zain A. Nadeem (Allama Iqbal Medical College)	Mr. Nadeem has nothing to disclose.
Mahad Butt	Mahad Butt has nothing to disclose.
Hamza Ashraf	Hamza Ashraf has nothing to disclose.
Eeshal Fatima	Mr. Fatima has nothing to disclose.
Aimen Nadeem	Miss Nadeem has nothing to disclose.
Haider Ashfaq	Haider Ashfaq has nothing to disclose.
Ahmed Raza	Ahmed Raza has nothing to disclose.
Sophia Ahmed, MBBS	Miss Ahmed has nothing to disclose.

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