Abstract Details

Title EEG Slowing Increases the Risk of Future Dementia: A Population-Based Cohort Study

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P9 - Poster Session 9 (11:45 AM-12:45 PM)

Poster/Presentation
Number 3-003

Objective To investigate whether electroencephalogram (EEG) slowing in cognitively healthy adults in the general population predicts future dementia diagnosis.

Background EEG slowing is commonly seen in dementia. However, it is unclear whether EEG slowing in the absence of cognitive impairment is predictive of future dementia.

Design/Methods 2800 cognitively unimpaired older adults from the Osteoporotic Fractures in Men Study (MrOS) and the Study of Osteoporotic Fractures (SOF) underwent in-home polysomnography (PSG) at baseline and returned for follow-up during the subsequent 12 years. Theta-to-alpha ratio (TAR) was calculated during non-REM sleep using power spectral analysis of the EEG. Multivariable logistic regression was used to estimate odds ratios (OR) for incident dementia according to quartiles of baseline TAR.

Results Compared with participants in the lowest quartile of TAR, those in the highest quartile had a 2.2-fold risk of developing dementia in MrOS and a 10.0-fold risk of developing dementia in SOF (P’s <0·01). Furthermore, a higher TAR at baseline and greater increase in TAR over time, were associated with greater genetic risk for dementia, faster cognitive decline, faster epigenetic ageing measured by DunedinPACE, and increased risk of all-cause mortality (P’s <0·05).

Conclusions

EEG slowing during sleep predicts future dementia and accelerated ageing in cognitively unimpaired men and women in the general population.

Authors/Disclosures
Abidemi Otaiku, MD PRESENTER	Dr. Otaiku has nothing to disclose.
Gregory P. Scott, MBBS (Imperial College London)	The institution of Dr. Scott has received personal compensation in the range of $500-$4,999 for serving as a Consultant for HelpFirst.
Sharp J. David, MBBS, PhD (Imperial College London)	The institution of Prof. David has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Rugby Football Union. Prof. David has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Guarantors of Brain. The institution of Prof. David has received research support from UK Dementia Research Institute. The institution of Prof. David has received research support from ADVANCE Charity. The institution of Prof. David has received research support from Action Medical Research. The institution of Prof. David has received research support from Medical Research Council UK.

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