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Abstract Details

The Monocyte-to-HDL ratio (MHR) as a prognostic and diagnostic biomarker in Acute Ischemic Stroke: A systematic review with meta-analysis
Cerebrovascular Disease and Interventional Neurology
P9 - Poster Session 9 (11:45 AM-12:45 PM)
14-010
To summarize the current evidence on the diagnostic and prognostic value of Monocyte-to-HDL ratio (MHR) on acute ischemic stroke (AIS)
Recently, the MHR has been studied as a potential biomarker for assessing the prognosis of different diseases.
We searched 5 databases (PubMed, Embase, Scopus, Web of Science and Google Scholar) until June 2024. We included observational studies that evaluated the association between MHR and AIS. A meta-analysis using a random-effects model to estimate pooled effects was planned for each outcome and a narrative synthesis when this was not possible. The Newcastle-Ottawa scale was used to assess the risk of bias and GRADE criteria were used to identify the certainty of evidence. 

11 studies (7 cohorts, 3 cross-sectionals and 1 case-control) were included. With high uncertainty, a meta-analysis of 4 studies showed a significantly increased risk of AIS in patients with a higher MHR (MD: 2.14, 95%CI: 1.75 to 2.54, I2: 100%, 4 studies). Regarding AIS prognosis, two separate meta-analysis were conducted on 30-day mortality and functional outcome. With high uncertainty, the MHR was found to be higher in deceased patients within 30 days of AIS onset (MD: 3.22, 95%CI: -3.28 to 9.72, I2: 99%, 2 studies), and higher in patients with mRS score >2 at 90 days (MD: 0.15, 95%CI: -0.05 to 0.34, I2: 87%, 2 studies). Additionally, all studies reported a low risk of bias.

With high uncertainty, we found that MHR is a useful tool for the diagnosis and prediction of poor outcomes in AIS. However, we need more studies, especially prospective ones, in order to improve the evidence regarding this index.

Authors/Disclosures
Jeancarlo Velazco
PRESENTER 		Mr. Velazco has nothing to disclose.
Gerardo M. Luna-Peralta Mr. Luna-Peralta has nothing to disclose.
Wagner Rios-Garcia Mr. Rios-Garcia has nothing to disclose.
Fritz F. Vascones Roman, Sr. Mr. Vascones Roman has nothing to disclose.
Ivan Alegre-Cordero Mr. Alegre-Cordero has nothing to disclose.
Gianfranco Carbajal, MS Mr. Carbajal has nothing to disclose.
Carlos Rodrigo Q. Vicuña Mr. Vicuña has nothing to disclose.