MS is a chronic immune-mediated disease affecting more than 2 million people worldwide. Coexistence with other autoimmune disorders, such as systemic lupus erythematosus (SLE), are well described. However, there is less known regarding MS patients concurrently diagnosed with scleroderma or ankylosing spondylitis.

All nine patients with coexisting relapsing-remitting MS and scleroderma are female, with an average age of 45 (±14.47) at MS diagnosis. Six were previous smokers with an average 15 pack-years (±11.83). Hypertension was diagnosed in four patients, hyperlipidemia in two, and thyroid cancer in one. Autoimmune comorbidities included SLE in three, hypothyroidism in two, and rheumatoid arthritis in one. Psychological comorbidities included depression and anxiety in three patients, separately. At MS diagnosis, eight had abnormal brain MRIs while three had cervical and thoracic lesions. CSF data from four patients showed an average cell count of 22.75/μL (±5.18), glucose of 101.67 mg/dL (±15.94), protein of 36.5 mg/dL (±22.72), and IgG index of 5.12 mg/dL (±5.36). Five patients had 3 or more oligoclonal bands in CSF only. The average vitamin D level was 29 ng/mL (±18.71).