好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Blood-Based Biomarkers of Systemic Inflammation, Metabolic Function, and Vascular Injury Distinguish Patients with Rapid and Typical Progressive Neurodegenerative Diseases
Aging, Dementia, and Behavioral Neurology
P9 - Poster Session 9 (11:45 AM-12:45 PM)
3-020
Evaluate the ability of blood-based biomarkers of systemic inflammation, metabolic function, and vascular injury to distinguish patients with rapid and typical progressive Alzheimer disease and related dementias (AD/ADRD).
Selected CSF biomarkers of neuronal injury (NfL, VILIP-1), AD neuropathology (p-tau181), and neuroinflammation (GFAP, MCP-1, sTREM2) measured at presentation associate with etiologic diagnoses and reliably differentiate patients with treatment-responsive causes of rapid progressive dementia. However, these same biomarkers do not differentiate between patients with rapid and typical progressive forms of AD/ADRD, leaving unanswered key questions concerning the mechanisms that drive rpAD/ADRD. Blood-based biomarkers may inform the systemic factors that contribute to rpAD/ADRD, including the systemic inflammation, metabolic function, and vascular injury.
Biomarkers of systemic inflammation, metabolic function, and vascular injury were measured using Meso Scale Discovery multiplexed assays in plasma obtained at presentation from patients with rpAD/ADRD (n=29), and age- and sex- similar participants with typical progressive AD/ADRD (n=39) enrolled in parallel studies of memory and aging. Biomarker concentrations were compared between groups using univariate analyses. Potential predictors (p<0.05) were further evaluated via stepwise multivariate logistic regression.
Markers of vascular injury (SAA, CRP, sICAM-1), metabolic function (I-309, TPO), and systemic inflammation (Eotaxin-3, TARC, TNF-α) were increased in patients with rapid versus typical progressive AD/ADRD (p<0.05). Eotaxin-3, I-309, and SAA were independently associated with rpAD/ADRD, after controlling for age and sex. The overall multivariate model correctly characterized 87% of patients, with an area under the curve of 0.90 (95%CI: 0.83-0.98; p<0.001).

Blood-based biomarkers of systemic inflammation, metabolic function, and vascular injury were elevated at presentation in patients with rapid vs typical AD/ADRD. These findings may provide additional insights into the mechanisms that drive rpAD/ADRD. Longitudinal measures from larger cohorts are needed to decipher the relationship between candidate biomarkers and rpAD/ADRD.
Authors/Disclosures
Gregory S. Day, MD, MSc, FAAN (Mayo Clinic)
PRESENTER 		Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arialys Therapeutics. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for DynaMed (EBSCO Health). Dr. Day has or had stock in ANI Pharmaceuticals. The institution of Dr. Day has received research support from National Institutes of Health / NIA. The institution of Dr. Day has received research support from National Institutes of Health / NINDS. The institution of Dr. Day has received research support from Amgen Pharmaceuticals. The institution of Dr. Day has received research support from AVID Radiopharmaceuticals. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Presenter at Annual Meeting (CME) with 好色先生. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Content Development (CME) with PeerView, Inc. Dr. Day has received personal compensation in the range of $5,000-$9,999 for serving as a Content Development (CME) with Continuing 好色先生, Inc. Dr. Day has received personal compensation in the range of $5,000-$9,999 for serving as a Content Development (CME) with Ionis Pharmaceuticals. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a 好色先生al Case Development + Presentation (video) with PeerDirect (P\S\L Group). Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Content Development / Presentation (non-CME) with MJH Life Sciences (NeurologyLive). Dr. Day has a non-compensated relationship as a Clinical Director with Anti-NMDA Receptor Encephalitis Foundation that is relevant to AAN interests or activities.
Lindsey Kuchenbecker Lindsey Kuchenbecker has nothing to disclose.
Philip W. Tipton, MD Dr. Tipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie. Dr. Tipton has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Alzheimer's Tennessee. Dr. Tipton has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Charlotte County Medical Society, Inc.
Matthew Brier, MD, PhD (Washington University) Dr. Brier has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. The institution of Dr. Brier has received research support from NIH.
Nihal Satyadev, MD, MPH (Mayo Clinic) Dr. Satyadev has nothing to disclose.
Yoav Piura, MD Dr. Piura has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. Dr. Piura has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck.
Steven R. Dunham, Jr., MD Dr. Dunham has nothing to disclose.
Sid E. O'Bryant, PhD (UNT INST FOR TRANSLATIONAL RESEARCH) Dr. O'Bryant has nothing to disclose.
Neill R. Graff-Radford, MD, FAAN (Mayo Clinic Jacksonville) The institution of Dr. Graff-Radford has received research support from Biogen. The institution of Dr. Graff-Radford has received research support from Lilly. The institution of Dr. Graff-Radford has received research support from Eisai. The institution of Dr. Graff-Radford has received research support from Biogen. Dr. Graff-Radford has received publishing royalties from a publication relating to health care.