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Abstract Details

Resting-state EEG Characteristics in Autopsy-confirmed Cohorts of Dementia with Lewy Bodies and Alzheimer’s Disease
Aging, Dementia, and Behavioral Neurology
S15 - Diagnostics, Mechanics, and Mortality of Alzheimer's Disease and Related Dementias (2:24 PM-2:36 PM)
008
To compare quantitative resting-state electroencephalography (rsEEG) in pathologically confirmed cohorts of dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD)
Posterior slowing on rsEEG is a supportive biomarker in DLB. EEG shows promise for distinguishing dementia subtypes but lacks validation in autopsy confirmed cases.
We identified pathologically diagnosed DLB cases from the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND), with baseline antemortem rsEEG (1 min each with eyes open and closed conditions). We included data from AD (n=44) and non-demented controls (n=50), who were age- and sex-matched to the DLB group (n=27). We compared dominant frequency, aperiodic components, and alpha reactivity after accounting for aperiodic components from occipital electrodes (O1, Oz, O2).
There was no group difference in baseline age, sex, age at death, or time from EEG to death. Baseline Mini-Mental State Exam scores were lowest in DLB (24.7±7.1), followed by AD (26.1±5.0) and controls (28.7±1.5) (p<0.005). Most DLB individuals had Unified Staging System for Lewy Body Disorders stage IV (n=20, 74%). Mean Braak stage was lower in DLB (4.3±0.7) compared to AD (4.8±0.8) (p<0.001). Dominant frequency was significantly slower (p<0.001) in DLB (8.03 Hz ±1.30), compared to AD (8.75 Hz ±1.08) and controls (9.26 Hz ±1.22). Aperiodic components differed (p<0.001), with DLB exhibiting a significantly steeper slope (1.38±0.49), compared to AD (1.15±0.38) and controls (0.97±0.36). Alpha reactivity was significantly reduced (p<0.01) in DLB (0.34±0.34), compared to AD (0.55±0.28) and controls (0.55±0.30), after controlling for aperiodic components.
rsEEG dominant frequency was significantly slower in DLB, consistent with prior studies. Few have characterized aperiodic and oscillatory EEG abnormalities in DLB. We identified distinct aperiodic activity (steeper slope) and a novel reduction in alpha reactivity after controlling for aperiodic components in pathologically confirmed DLB, compared to AD and controls. Longitudinal studies are needed to further validate rsEEG in DLB.
Authors/Disclosures
Shannon Y. Chiu, MD, MSc (Mayo Clinic Arizona)
PRESENTER 		Dr. Chiu has received research support from NIH.
Jinhan Park Mr. Park has nothing to disclose.
Nan Zhang Nan Zhang has nothing to disclose.
Sotiris G. Mitropanopoulos, MD (Mayo Clinic) Dr. Mitropanopoulos has nothing to disclose.
John N. Caviness, MD, FAAN (Mayo Clinic) Dr. Caviness has nothing to disclose.
Chris Harris, R EEG T Mr. Harris has nothing to disclose.
Charles H. Adler, MD, PhD, FAAN (Mayo Clinic Arizona) Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avion. Dr. Adler has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CND Life Sci. Dr. Adler has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Jazz. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Precon. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. The institution of Dr. Adler has received research support from NIH. The institution of Dr. Adler has received research support from Michael J. Fox Foundation. The institution of Dr. Adler has received research support from Arizona Biomedical Research Commission. Dr. Adler has received publishing royalties from a publication relating to health care.
Holly A. Shill, MD, FAAN (Barrow Neurology Clinics) Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sage Biogen. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for KeifeRx. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Praxis Precision Medicine. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Fasikl Inc. Dr. Shill has received personal compensation in the range of $0-$499 for serving as a Consultant for Boston Scientific. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi Tanabe Pharma America.
Shyamal Mehta, MD, PhD, FAAN (Mayo Clinic, Arizona) Dr. Mehta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Adamas Pharma. Dr. Mehta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Abbott. Dr. Mehta has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CNS Ratings.
Erika Driver-Dunckley, MD, FAAN Dr. Driver-Dunckley has nothing to disclose.
Parichita Choudhury, MD (Banner Sun Health Research Institute) The institution of Dr. Choudhury has received research support from Lewy Body Dementia Association. The institution of Dr. Choudhury has received research support from Arizona Alzheimer's Consortium.
Cecilia Tremblay (Banner Sun Health Research Institute) Cecilia Tremblay has nothing to disclose.
Christine Belden Christine Belden has nothing to disclose.
Geidy Serrano Geidy Serrano has nothing to disclose.
Thomas Beach (Banner Sun Health Research Institute) Thomas Beach has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vivid Genomics. Thomas Beach has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche Diagnostics. The institution of Thomas Beach has received research support from National Institutes of Health. The institution of Thomas Beach has received research support from Michael J Fox Foundation . The institution of Thomas Beach has received research support from State of Arizona.
Alireza Atri, MD, PhD (Banner Sun Health Research Institute) Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Prothena. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eisai. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novo Nordisk. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Atri has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Life Molecular Imaging. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novo Nordisk. Dr. Atri has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche/Genentech. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lunbeck. Dr. Atri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ONO. Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Axsome. Dr. Atri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AriBio. Dr. Atri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Vaxxinity. The institution of Dr. Atri has received research support from National Institute of Aging (NIA). The institution of Dr. Atri has received research support from AZ Department of Health Services. The institution of Dr. Atri has received research support from Gates Ventures. The institution of Dr. Atri has received research support from Multiple companies, universities & consortia for contracted clinical trials to institution. The institution of Dr. Atri has received research support from Washington University in St. Louis. The institution of Dr. Atri has received research support from Foundation for NIH. The institution of Dr. Atri has received research support from ACTC/NIH. Dr. Atri has received publishing royalties from a publication relating to health care.
David Vaillancourt David Vaillancourt has received personal compensation for serving as an employee of Automated Imaging Diagnostics. David Vaillancourt has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. The institution of David Vaillancourt has received research support from NIH. David Vaillancourt has received intellectual property interests from a discovery or technology relating to health care.
Stephen Coombes, PhD Dr. Coombes has received personal compensation in the range of $10,000-$49,999 for serving as a partner with Neuroimaging Solutions LLC.