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2026 Annual Meeting | S15 - Diagnostics, Mechanics, and Mortality of Alzheimer's Disease and Related Dementias

Monday 04/20/26
01:00 PM - 03:00 PM CDT Add To Calendar
McCormick Place West | W185bc
This program will be presented both in-person and online
This program will be available in the meeting's On Demand product.
Scientific Platform Session
Claire E. Delpirou Nouh, MD, Kathy L. Niu, MD
Aging, Dementia, and Behavioral Neurology
2.00 CME credits

Program Materials

Event Timeline
01:00 PM - 01:12 PM CDT Speaker 2026 Norman Geschwind Prize in Behavioral Neurology: This prize is awarded to an individual for outstanding research in the field of behavioral neurology
Juan B. Toledo Atucha, MD, PhD
01:12 PM - 01:24 PM CDT Speaker 2026 S. Weir Mitchell Resident-Fellow Research Award: This award is designed to encourage research in neuroscience by physicians in neurology training program
Nardin Samuel, MD, PhD
01:12 PM - 01:24 PM CDT Abstract 002 - Deep Learning-enhanced EEG Preprocessing for Early Alzheimer’s Disease Detection
Nardin Samuel, MD, PhD
01:24 PM - 01:36 PM CDT Abstract 003 - Metabolomic Interactions Between Alzheimer’s and Metabolic Diseases: Insights from the Nightingale–Mass General Brigham Biobank
Ezgi Sila Toklucu
01:36 PM - 01:48 PM CDT Abstract 004 - Rising Mortality Related to Early-Onset Alzheimer’s Disease in the United States: Trends and Disparities 2003-2023
Keara Kennedy
01:48 PM - 02:00 PM CDT Abstract 005 - Impacts of Menopausal Hormone Therapy on Alzheimer's Disease Biomarkers: A Systematic Review
Amanda C. Rodrigues, MS
02:12 PM - 02:24 PM CDT Abstract 007 - Native Methylation Sequencing for Detection and Monitoring of Alzheimer’s Disease, Parkinson’s and ALS
Jonathon T. Hill, PhD
02:24 PM - 02:36 PM CDT Abstract 008 - Resting-state EEG Characteristics in Autopsy-confirmed Cohorts of Dementia with Lewy Bodies and Alzheimer’s Disease
Shannon Y. Chiu, MD, MSc
02:36 PM - 02:48 PM CDT Abstract 009 - MS4A6A/Ms4a6d Deficiency Disrupts Neuroprotective Microglia Functions and Promotes Inflammation in Alzheimer’s Disease Model
Haishan Jiao, PhD
02:48 PM - 03:00 PM CDT Abstract 010 - Preclinical Tau Deposition is Associated with Reduction of the DMN Deactivation During Episodic Memory Tasks
Bardiya Ghaderi Yazdi, MD
Faculty Disclosures
Claire E. Delpirou Nouh, MD The institution of Dr. Delpirou Nouh has received research support from Oklahomas Nathan Shock Center. Dr. Delpirou Nouh has a non-compensated relationship as a Volunteer/Board member with Oklahoma Alzheimer Association that is relevant to AAN interests or activities.
Kathy L. Niu, MD Dr. Niu has nothing to disclose.
Nardin Samuel, MD, PhD Dr. Samuel has received personal compensation for serving as an employee of Cove Neurosciences Inc..
Juan B. Toledo Atucha, MD, PhD Dr. Toledo Atucha has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GLG Consulting. Dr. Toledo Atucha has received personal compensation in the range of $0-$499 for serving as a Consultant for SpearBio. Dr. Toledo Atucha has received personal compensation in the range of $0-$499 for serving as a Consultant for Newell. Dr. Toledo Atucha has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia Pharmaceuticals. The institution of Dr. Toledo Atucha has received research support from NIH. Dr. Toledo Atucha has received personal compensation in the range of $500-$4,999 for serving as a Clinical Trials Deputy Section Editor with Alzheimer's & Dementia Jouranl.
Parichita Choudhury, MD The institution of Dr. Choudhury has received research support from Lewy Body Dementia Association. The institution of Dr. Choudhury has received research support from Arizona Alzheimer's Consortium.
Shannon Y. Chiu, MD, MSc Dr. Chiu has received research support from NIH.
Thomas Beach Thomas Beach has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vivid Genomics. Thomas Beach has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche Diagnostics. The institution of Thomas Beach has received research support from National Institutes of Health. The institution of Thomas Beach has received research support from Michael J Fox Foundation . The institution of Thomas Beach has received research support from State of Arizona.
Stephen Coombes, PhD Dr. Coombes has received personal compensation in the range of $10,000-$49,999 for serving as a partner with Neuroimaging Solutions LLC.
Sindy ozoria blake Mrs. ozoria blake has nothing to disclose.
Sotiris G. Mitropanopoulos, MD Dr. Mitropanopoulos has nothing to disclose.
Jean-Claude Provost, MD Dr. Provost has received personal compensation for serving as an employee of Lantheus.
Bardiya Ghaderi Yazdi, MD Dr. Ghaderi Yazdi has nothing to disclose.
Antoine Leuzy, PhD Dr. Leuzy has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Enigma Biomedical Group.
Xiuyuan H. Wang Mr. Wang has nothing to disclose.
Holly A. Shill, MD, FAAN Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sage Biogen. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for KeifeRx. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Praxis Precision Medicine. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Fasikl Inc. Dr. Shill has received personal compensation in the range of $0-$499 for serving as a Consultant for Boston Scientific. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi Tanabe Pharma America.
Wenchao Chen, PhD Dr. Chen has nothing to disclose.
Peng Yuan Dr. Yuan has received personal compensation for serving as an employee of Fudan University. The institution of Dr. Yuan has received research support from Fudan University.
Serge G. Gauthier, MD Dr. Gauthier has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for TauRx . Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly Canada . Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai . Dr. Gauthier has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ENIGMA USA. Dr. Gauthier has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AmyriAD. Dr. Gauthier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medesis. Dr. Gauthier has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Alzheon. Dr. Gauthier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Karuna. Dr. Gauthier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Otsuka . Dr. Gauthier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NovoNordisk. Dr. Gauthier has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen Canada. Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving as an officer or member of the Board of Directors for Sharon Francis Foundation . Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JPAD. Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Lundbeck Foundation . Dr. Gauthier has received publishing royalties from a publication relating to health care.
Christopher C. Rowe, MD, PhD Prof. Rowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Nordisk. Prof. Rowe has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Prothena. Prof. Rowe has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai Australia. Prof. Rowe has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly Australia. Prof. Rowe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche Diagnostics. Prof. Rowe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Prof. Rowe has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Novo Nordisk. Prof. Rowe has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche Diagnostics. Prof. Rowe has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Johnson and Johnson. The institution of Prof. Rowe has received research support from Enigma. The institution of Prof. Rowe has received research support from Australian Dementia Network Ltd. The institution of Prof. Rowe has received research support from National Health and Medical Research Council. The institution of Prof. Rowe has received research support from Florey Institute of Neuroscience.
Elizabeth Karlson, MD Dr. Karlson has nothing to disclose.
Haishan Jiao, PhD Dr. Jiao has nothing to disclose.
Jonathon T. Hill, PhD Dr. Hill has received personal compensation for serving as an employee of Wasatch Biolabs. Dr. Hill has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Renew Biotechnology. Dr. Hill has or had stock in Wasatch Biolabs.Dr. Hill has or had stock in Pioneer Biolabs.Dr. Hill has received research support from NIH. Dr. Hill has received research support from Utah State Alzheimer's Fund. Dr. Hill has received research support from Society for Developmental Biology. Dr. Hill has received research support from Fulbright Commission. Dr. Hill has received research support from Renew Biotechnologies. Dr. Hill has received intellectual property interests from a discovery or technology relating to health care.
Matthew J. Miller, PhD, PT The institution of Dr. Miller has received research support from NIH.
Andy Song, Medical Student Mr. Song has nothing to disclose.
Carolina B. Moura, MD Dr. Moura has nothing to disclose.
Irene E. Harmsen, MD, PhD Dr. Harmsen has nothing to disclose.
Susan Landau, PhD Dr. Landau has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for KeifeRx. Dr. Landau has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai, Inc. The institution of Dr. Landau has received research support from NIH.
Filipe G. Valerio Mr. Valerio has nothing to disclose.
Erika Driver-Dunckley, MD, FAAN Dr. Driver-Dunckley has nothing to disclose.
Jin-Tai Yu, PhD Prof. Yu has nothing to disclose.
Ray Razlighi, PhD Prof. Razlighi has nothing to disclose.
Alireza Atri, MD, PhD Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Prothena. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eisai. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novo Nordisk. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Atri has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Life Molecular Imaging. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novo Nordisk. Dr. Atri has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche/Genentech. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lunbeck. Dr. Atri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ONO. Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Axsome. Dr. Atri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AriBio. Dr. Atri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Vaxxinity. The institution of Dr. Atri has received research support from National Institute of Aging (NIA). The institution of Dr. Atri has received research support from AZ Department of Health Services. The institution of Dr. Atri has received research support from Gates Ventures. The institution of Dr. Atri has received research support from Multiple companies, universities & consortia for contracted clinical trials to institution. The institution of Dr. Atri has received research support from Washington University in St. Louis. The institution of Dr. Atri has received research support from Foundation for NIH. The institution of Dr. Atri has received research support from ACTC/NIH. Dr. Atri has received publishing royalties from a publication relating to health care.
Kenji Ishii, MD Dr. Ishii has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Enigma Biomedical. Dr. Ishii has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Nihon MediPhysics Co., Ltd.. Dr. Ishii has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for PDRadiopharma Inc.. Dr. Ishii has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Eli Lilly Japan K.K.. The institution of Dr. Ishii has received research support from Nihon MediPhysics Co., Ltd..
Sterling Johnson, PhD Prof. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Prof. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alamar. Prof. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Prof. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sunbird bio. Prof. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Enigma Biomedical.
Keith A. Johnson, MD Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AC Immune. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Shionogi. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Prothena. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NervGen. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Oligomerix. Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AC Immune. The institution of Dr. Johnson has received research support from National Institute on Aging. The institution of an immediate family member of Dr. Johnson has received research support from Alzheimer's Association. The institution of an immediate family member of Dr. Johnson has received research support from Eli Lilly and Co. The institution of Dr. Johnson has received research support from Eisai. The institution of an immediate family member of Dr. Johnson has received research support from Eisai.
Luca Passamonti, MD, PhD Dr. Passamonti has received personal compensation for serving as an employee of Lantheus. Dr. Passamonti has stock in Lantheus.
Charles H. Adler, MD, PhD, FAAN Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avion. Dr. Adler has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CND Life Sci. Dr. Adler has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Jazz. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Precon. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. The institution of Dr. Adler has received research support from NIH. The institution of Dr. Adler has received research support from Michael J. Fox Foundation. The institution of Dr. Adler has received research support from Arizona Biomedical Research Commission. Dr. Adler has received publishing royalties from a publication relating to health care.
David Scott, PhD Mr. Scott has nothing to disclose.
John N. Caviness, MD, FAAN Dr. Caviness has nothing to disclose.
Chris Harris, R EEG T Mr. Harris has nothing to disclose.
Emma Russo Ms. Russo has received personal compensation in the range of $0-$499 for serving as a Consultant for Cove Neurosciences. Ms. Russo has a non-compensated relationship as a Director of Clinical R&D with Cove Neurosciences that is relevant to AAN interests or activities.
Shyamal Mehta, MD, PhD, FAAN Dr. Mehta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Adamas Pharma. Dr. Mehta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Abbott. Dr. Mehta has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CNS Ratings.
Peter Chernek, MPH Mr. Chernek has nothing to disclose.
Christine Belden Christine Belden has nothing to disclose.
Gabriel C. Tudella Mr. Tudella has nothing to disclose.
Geidy Serrano Geidy Serrano has nothing to disclose.
Hartmuth C. Kolb, PhD Dr. Kolb has received personal compensation for serving as an employee of Enigma Biomedical Group. Dr. Kolb has received personal compensation for serving as an employee of Johnson & Johnson. Dr. Kolb has received personal compensation for serving as an employee of University of Wisconsin, Madison. Dr. Kolb has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AviadoBio. Dr. Kolb has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alector. Dr. Kolb has stock in Johnson & Johnson.
Maura Hackett, Medical student Ms. Hackett has nothing to disclose.
Jinhan Park Mr. Park has nothing to disclose.
David Vaillancourt David Vaillancourt has received personal compensation for serving as an employee of Automated Imaging Diagnostics. David Vaillancourt has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. The institution of David Vaillancourt has received research support from NIH. David Vaillancourt has received intellectual property interests from a discovery or technology relating to health care.
Ezgi Sila Toklucu Miss Toklucu has nothing to disclose.
Evanthia Bernitsas, MD, FAAN Dr. Bernitsas has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Bernitsas has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Vanda. The institution of Dr. Bernitsas has received research support from Roche/Genentech.
Keara Kennedy Miss Kennedy has nothing to disclose.
Leo Lin, MD, PhD Dr. Lin has nothing to disclose.
Diogo Haddad Santos, MD Dr. Haddad Santos has nothing to disclose.
Jenseric Calimag Mr. Calimag has nothing to disclose.
Cecilia Tremblay Cecilia Tremblay has nothing to disclose.
Eric Zimmerman Mr. Zimmerman has nothing to disclose.
Himanshu Verma, MBBS Dr. Verma has nothing to disclose.
Koen J. Van Laere, MD, PhD Prof. Van Laere has nothing to disclose.
Carlos Eduardo Monforte de Oliveira Mr. Monforte de Oliveira has nothing to disclose.
Samantha Budd Haeberlein, PhD Dr. Budd Haeberlein has received personal compensation for serving as an employee of Enigma Biomedical. Dr. Budd Haeberlein has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Vigil Neuroscience.
Nan Zhang Nan Zhang has nothing to disclose.
Chad A. Pollard Mr. Pollard has received personal compensation for serving as an employee of Renew Biotechnologies. Mr. Pollard has stock in Renew Biotechnologies. Mr. Pollard has received intellectual property interests from a discovery or technology relating to health care.
Ali M. Al-Salahat, MBBS Dr. Al-Salahat has nothing to disclose.
Amanda C. Rodrigues, MS Miss Rodrigues has nothing to disclose.
Nancy Stambler, PhD Dr. Stambler has received personal compensation for serving as an employee of Lantheus. Dr. Stambler has stock in Lantheus.
Sulantha Mathotaarachchi Mr. Mathotaarachchi has nothing to disclose.
Anderson Matheus P da Silva, Sr., PhD Prof. P da Silva has nothing to disclose.
Haoqi Sun, PhD Dr. Sun has nothing to disclose.
Jessica Lasky Su, ScD Dr. Lasky Su has nothing to disclose.
Alison Long, MD, PhD Dr. Long has received personal compensation for serving as an employee of Enigma Biomedical Group. Dr. Long has received personal compensation in the range of $0-$499 for serving as a Consultant for Enigma Biomedical Group. Dr. Long has received personal compensation in the range of $50,000-$99,999 for serving as an officer or member of the Board of Directors for Taysha Gene Therapies. Dr. Long has stock in Taysha Gene Therapies. Dr. Long has stock in Meilleur. Dr. Long has stock in Enigma Biomedical Group.
Eric M. Reiman, MD Dr. Reiman has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Denali, Green Valley, Zinfandel, and Takeda. Dr. Reiman has received stock or an ownership interest from Alkahest, Alzheon, Aural Analytics, Denali, and United Neuroscience.. Dr. Reiman has received intellectual property interests from a discovery or technology relating to health care. Dr. Reiman has received personal compensation in the range of $500-$4,999 for serving as a Member, National Advisory Council on Aging (NACA) with NIA.
Can Zhang, MD, PhD The institution of Dr. Zhang has received research support from NIH. The institution of Dr. Zhang has received research support from ADDF. The institution of Dr. Zhang has received research support from Cure Alzheimer's Fund. Dr. Zhang has received intellectual property interests from a discovery or technology relating to health care.
Tim Jenkins, PhD Dr. Jenkins has received personal compensation for serving as an employee of Renew Biotechnologies. Dr. Jenkins has stock in Renew Biotechnologies. The institution of Dr. Jenkins has received research support from Renew Biotechnologies. The institution of Dr. Jenkins has received research support from NIH. Dr. Jenkins has received intellectual property interests from a discovery or technology relating to health care.
Ryan Miller Mr. Miller has received personal compensation for serving as an employee of Resonant. Mr. Miller has stock in Inherent Biosciences. Mr. Miller has received intellectual property interests from a discovery or technology relating to health care.
Hailey E. Zimmerman Mrs. Zimmerman has received personal compensation for serving as an employee of Renew Biotechnologies.